J
Jean-Pierre Etchegaray
Researcher at Rutgers University
Publications - 45
Citations - 4054
Jean-Pierre Etchegaray is an academic researcher from Rutgers University. The author has contributed to research in topics: Epigenetics & Circadian clock. The author has an hindex of 19, co-authored 41 publications receiving 3527 citations. Previous affiliations of Jean-Pierre Etchegaray include University of Medicine and Dentistry of New Jersey & University of Massachusetts Medical School.
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Journal ArticleDOI
Posttranslational mechanisms regulate the mammalian circadian clock.
Choogon Lee,Jean-Pierre Etchegaray,Felino R. Cagampang,Andrew S. I. Loudon,Steven M. Reppert +4 more
TL;DR: Analysis of clock proteins in m CRY-deficient mice shows that the mCRYs are necessary for stabilizing phosphorylated mPER2 and for the nuclear accumulation of mPER1, mper2, and CKIepsilon, and provides in vivo evidence that casein kinase I delta is a second clock relevant kinase.
Journal ArticleDOI
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock
TL;DR: It is shown that transcriptional regulation of the core clock mechanism in mouse liver is accompanied by rhythms in H3 histone acetylation, and that H3 acetylations is a potential target of the inhibitory action of Cry.
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Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes
TL;DR: Molecular pathways and their metabolites associated with epigenetic adaptations modulated by histone- and DNA-modifying enzymes and their responsiveness to the environment in the context of health and disease are reviewed.
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High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase
Tsuyoshi Hirota,Jae Wook Lee,Jae Wook Lee,Warren G. Lewis,Warren G. Lewis,Eric E. Zhang,Eric E. Zhang,Ghislain Breton,Xianzhong Liu,Michael Garcia,Eric C. Peters,Jean-Pierre Etchegaray,David Traver,Peter G. Schultz,Peter G. Schultz,Steve A. Kay +15 more
TL;DR: A novel compound “longdaysin” was found to dramatically slow down the speed of the circadian clock through simultaneous inhibition of protein kinases CKIδ, CKIα, and ERK2.
Journal ArticleDOI
Casein kinase 1 delta regulates the pace of the mammalian circadian clock.
Jean-Pierre Etchegaray,Kazuhiko K. Machida,Elizabeth Noton,Cara M. Constance,Robert Dallmann,Marianne N. Di Napoli,Jason P. DeBruyne,Christopher M. Lambert,Elizabeth A. Yu,Steven M. Reppert,David R. Weaver +10 more
TL;DR: CK1δ plays an unexpectedly important role in maintaining the 24-h circadian cycle length, and disruption of the gene encoding CK1ε did not alter these circadian endpoints.