A Clock Shock: Mouse CLOCK Is Not Required for Circadian Oscillator Function
Jason P. DeBruyne,Elizabeth Noton,Christopher M. Lambert,Elizabeth S. Maywood,David R. Weaver,Steven M. Reppert +5 more
TLDR
The Cre-LoxP system is used to generate whole-animal knockouts of CLOCK and the resultant circadian phenotypes challenge a central feature of the current mammalian circadian clock model regarding the necessity of CLock:BMAL1 heterodimers for clock function.About:
This article is published in Neuron.The article was published on 2006-05-04 and is currently open access. It has received 422 citations till now. The article focuses on the topics: Circadian clock & CLOCK.read more
Citations
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Journal ArticleDOI
Molecular components of the mammalian circadian clock
TL;DR: The general mechanisms of the circadian clockwork are reviewed, recent findings that elucidate tissue-specific expression patterns of the clock genes are described and the importance of circadian regulation in peripheral tissues for an organism's overall well-being is addressed.
Book ChapterDOI
Molecular components of the Mammalian circadian clock
TL;DR: This work has shown that there are other molecular circadian oscillators which can act independently of the transcription-based clock in all species which have been tested.
Journal ArticleDOI
Post-translational modifications regulate the ticking of the circadian clock
Monica Gallego,David M. Virshup +1 more
TL;DR: Mutations in kinases and phosphatases in hamsters, flies, fungi and humans highlight how their timepieces are regulated and provide clues as to how the authors might be able to manipulate them.
Journal ArticleDOI
Intercellular Coupling Confers Robustness against Mutations in the SCN Circadian Clock Network
Andrew C. Liu,Andrew C. Liu,David K. Welsh,David K. Welsh,David K. Welsh,Caroline H. Ko,Caroline H. Ko,Hien G. Tran,Hien G. Tran,Eric E. Zhang,Eric E. Zhang,Aaron A. Priest,Ethan D. Buhr,Oded Singer,Kirsten Meeker,Inder M. Verma,Francis J. Doyle,Joseph S. Takahashi,Joseph S. Takahashi,Steve A. Kay +19 more
TL;DR: These studies reveal previously unappreciated requirements for Per1, Per2, and Cry1 in sustaining cellular circadian rhythmicity and demonstrate that SCN intercellular coupling is essential not only to synchronize component cellular oscillators but also for robustness against genetic perturbations.
Journal ArticleDOI
System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock
TL;DR: The finding that rhythmic mPer2 expression can be driven by both systemic cues and local oscillators suggests a plausible mechanism for the phase entrainment of subsidiary clocks in peripheral organs.
References
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Journal ArticleDOI
Coordination of circadian timing in mammals
TL;DR: Circadian rhythms are generated by one of the most ubiquitous and well-studied timing systems and are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.
Journal ArticleDOI
Molecular Bases for Circadian Clocks
TL;DR: It used to be that research in chronobiology moved biochemical functions [transcriptional activators], the along at a gentlemanly pace, but by mid 1997 the word in determining what the authors perceive as time was PASWCCLK.
Journal ArticleDOI
The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator.
Nicolas Preitner,Francesca Damiola,Luis-Lopez-Molina,J. Zakany,Denis Duboule,Urs Albrecht,Ueli Schibler +6 more
TL;DR: The orphan nuclear receptor REV-ERBalpha is identified as the major regulator of cyclic Bmal1 transcription, and constitutes a molecular link through which components of the negative limb drive antiphasic expression of component of the positive limb.
Journal ArticleDOI
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Nicholas Gekakis,David Staknis,David Staknis,David Staknis,Hubert B. Nguyen,Hubert B. Nguyen,Hubert B. Nguyen,Fred C. Davis,Fred C. Davis,Fred C. Davis,Lisa D. Wilsbacher,Lisa D. Wilsbacher,Lisa D. Wilsbacher,David P. King,David P. King,David P. King,Joseph S. Takahashi,Joseph S. Takahashi,Joseph S. Takahashi,Charles J. Weitz,Charles J. Weitz,Charles J. Weitz +21 more
TL;DR: CLOCK-BMAL1 heterodimers appear to drive the positive component of per transcriptional oscillations, which are thought to underlie circadian rhythmicity.
Journal ArticleDOI
Mutagenesis and Mapping of a Mouse Gene, Clock, Essential for Circadian Behavior
Martha Hotz Vitaterna,David P. King,Anne Marie Chang,Jon M. Kornhauser,Phillip L. Lowrey,J. David McDonald,J. David McDonald,William F. Dove,Lawrence H. Pinto,Fred W. Turek,Joseph S. Takahashi +10 more
TL;DR: The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals.