C
Christopher Schofield
Researcher at Ninewells Hospital
Publications - 12
Citations - 1083
Christopher Schofield is an academic researcher from Ninewells Hospital. The author has contributed to research in topics: Diabetes mellitus & Type 2 diabetes. The author has an hindex of 8, co-authored 12 publications receiving 1012 citations. Previous affiliations of Christopher Schofield include University of Dundee & Texas Biomedical Research Institute.
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Journal ArticleDOI
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
Kaixin Zhou,Kaixin Zhou,Céline Bellenguez,Chris C. A. Spencer,Amanda J. Bennett,Ruth L. Coleman,Ruth L. Coleman,Roger Tavendale,Roger Tavendale,Simon A. Hawley,Louise A. Donnelly,Louise A. Donnelly,Christopher Schofield,Christopher Schofield,Christopher J. Groves,Christopher J. Groves,Lindsay Burch,Lindsay Burch,Fiona Carr,Fiona Carr,Amy Strange,Colin Freeman,Jenefer M. Blackwell,Elvira Bramon,Elvira Bramon,Matthew A. Brown,Matthew A. Brown,Juan P. Casas,Juan P. Casas,Aiden Corvin,N. Craddock,Panos Deloukas,Panos Deloukas,Serge Dronov,Serge Dronov,A. Duncanson,Sarah Edkins,Sarah Edkins,Emma Gray,Emma Gray,Sarah E. Hunt,Sarah E. Hunt,Joachim Jankowski,Joachim Jankowski,Joachim Jankowski,Cordelia Langford,Cordelia Langford,Hugh S. Markus,Christopher G. Mathew,Robert Plomin,Anna Rautanen,Stephen Sawcer,Nilesh J. Samani,Nilesh J. Samani,Nilesh J. Samani,Richard C. Trembath,Ananth C. Viswanathan,Nicholas W. Wood,Lorna W. Harries,Lorna W. Harries,Andrew T. Hattersley,Andrew T. Hattersley,Alex S. F. Doney,Alex S. F. Doney,Helen M. Colhoun,Andrew D. Morris,Calum Sutherland,Calum Sutherland,D. G. Hardie,D. G. Hardie,Leena Peltonen,Mark I. McCarthy,Rury R. Holman,Colin N. A. Palmer,Colin N. A. Palmer,Peter Donnelly,Ewan R. Pearson +76 more
TL;DR: It is concluded that ATM, a gene known to be involved in DNA repair and cell cycle control, plays a role in the effect of metformin upstream of AMP-activated protein kinase, and variation in this gene alters glycemic response to meetformin.
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
Kaixin Zhou,Kaixin Zhou,Céline Bellenguez,Chris C. A. Spencer,Amanda J. Bennett,Ruth L. Coleman,Ruth L. Coleman,Roger Tavendale,Roger Tavendale,Simon A. Hawley,Louise A. Donnelly,Louise A. Donnelly,Christopher Schofield,Christopher Schofield,Christopher J. Groves,Christopher J. Groves,Lindsay Burch,Lindsay Burch,Fiona Carr,Fiona Carr,Amy Strange,Colin Freeman,Jenefer M. Blackwell,Elvira Bramon,Elvira Bramon,Matthew A. Brown,Matthew A. Brown,Juan P. Casas,Juan P. Casas,Aiden Corvin,N. Craddock,Panos Deloukas,Panos Deloukas,Serge Dronov,Serge Dronov,A. Duncanson,Sarah Edkins,Sarah Edkins,Emma Gray,Emma Gray,Sarah E. Hunt,Sarah E. Hunt,Joachim Jankowski,Joachim Jankowski,Joachim Jankowski,Cordelia Langford,Cordelia Langford,Hugh S. Markus,Christopher G. Mathew,Robert Plomin,Anna Rautanen,Stephen Sawcer,Nilesh J. Samani,Nilesh J. Samani,Nilesh J. Samani,Richard C. Trembath,Ananth C. Viswanathan,Nicholas W. Wood,Lorna W. Harries,Lorna W. Harries,Andrew T. Hattersley,Andrew T. Hattersley,Alex S. F. Doney,Alex S. F. Doney,Helen M. Colhoun,Andrew D. Morris,Calum Sutherland,Calum Sutherland,D. G. Hardie,D. G. Hardie,Leena Peltonen,Mark I. McCarthy,Rury R. Holman,Colin N. A. Palmer,Colin N. A. Palmer,Peter Donnelly,Ewan R. Pearson +76 more
TL;DR: A genome-wide association study for glycemic response to metformin in 1,024 Scottish individuals with type 2 diabetes with replication in two cohorts including 1,783 Scottish individuals and 1,113 individuals from the UK Prospective Diabetes Study.
Journal ArticleDOI
Mortality and hospitalization in patients after amputation: A comparison between patients with and without diabetes
Christopher Schofield,Gillian Libby,G. Brennan,Ritchie MacAlpine,Andrew D. Morris,Graham P. Leese +5 more
TL;DR: After LEA, patients with diabetes have an increased risk of death compared with nondiabetic patients, and efforts should be made to minimize these risks with aggressive treatment of cardiovascular risk factors and management of cardiac failure.
Journal ArticleDOI
Decreasing amputation rates in patients with diabetes-a population-based study.
TL;DR: To assess the changing rate of amputation in patients with diabetes over a 7‐year period, a large number of patients diagnosed with diabetes have had at least one amputation.
Journal ArticleDOI
Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes.
TL;DR: In this paper, the potential initiating defects in Type 2 diabetes, normal pulsatile insulin secretion and the effects that disordered secretion may have on both β-cell function and hepatic insulin sensitivity are discussed.