L
Lindsay Burch
Researcher at University of Dundee
Publications - 21
Citations - 2104
Lindsay Burch is an academic researcher from University of Dundee. The author has contributed to research in topics: Phosphorylation & Local ring. The author has an hindex of 18, co-authored 21 publications receiving 2009 citations. Previous affiliations of Lindsay Burch include University of Edinburgh & Texas Biomedical Research Institute.
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Journal ArticleDOI
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
Kaixin Zhou,Kaixin Zhou,Céline Bellenguez,Chris C. A. Spencer,Amanda J. Bennett,Ruth L. Coleman,Ruth L. Coleman,Roger Tavendale,Roger Tavendale,Simon A. Hawley,Louise A. Donnelly,Louise A. Donnelly,Christopher Schofield,Christopher Schofield,Christopher J. Groves,Christopher J. Groves,Lindsay Burch,Lindsay Burch,Fiona Carr,Fiona Carr,Amy Strange,Colin Freeman,Jenefer M. Blackwell,Elvira Bramon,Elvira Bramon,Matthew A. Brown,Matthew A. Brown,Juan P. Casas,Juan P. Casas,Aiden Corvin,N. Craddock,Panos Deloukas,Panos Deloukas,Serge Dronov,Serge Dronov,A. Duncanson,Sarah Edkins,Sarah Edkins,Emma Gray,Emma Gray,Sarah E. Hunt,Sarah E. Hunt,Joachim Jankowski,Joachim Jankowski,Joachim Jankowski,Cordelia Langford,Cordelia Langford,Hugh S. Markus,Christopher G. Mathew,Robert Plomin,Anna Rautanen,Stephen Sawcer,Nilesh J. Samani,Nilesh J. Samani,Nilesh J. Samani,Richard C. Trembath,Ananth C. Viswanathan,Nicholas W. Wood,Lorna W. Harries,Lorna W. Harries,Andrew T. Hattersley,Andrew T. Hattersley,Alex S. F. Doney,Alex S. F. Doney,Helen M. Colhoun,Andrew D. Morris,Calum Sutherland,Calum Sutherland,D. G. Hardie,D. G. Hardie,Leena Peltonen,Mark I. McCarthy,Rury R. Holman,Colin N. A. Palmer,Colin N. A. Palmer,Peter Donnelly,Ewan R. Pearson +76 more
TL;DR: It is concluded that ATM, a gene known to be involved in DNA repair and cell cycle control, plays a role in the effect of metformin upstream of AMP-activated protein kinase, and variation in this gene alters glycemic response to meetformin.
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
Kaixin Zhou,Kaixin Zhou,Céline Bellenguez,Chris C. A. Spencer,Amanda J. Bennett,Ruth L. Coleman,Ruth L. Coleman,Roger Tavendale,Roger Tavendale,Simon A. Hawley,Louise A. Donnelly,Louise A. Donnelly,Christopher Schofield,Christopher Schofield,Christopher J. Groves,Christopher J. Groves,Lindsay Burch,Lindsay Burch,Fiona Carr,Fiona Carr,Amy Strange,Colin Freeman,Jenefer M. Blackwell,Elvira Bramon,Elvira Bramon,Matthew A. Brown,Matthew A. Brown,Juan P. Casas,Juan P. Casas,Aiden Corvin,N. Craddock,Panos Deloukas,Panos Deloukas,Serge Dronov,Serge Dronov,A. Duncanson,Sarah Edkins,Sarah Edkins,Emma Gray,Emma Gray,Sarah E. Hunt,Sarah E. Hunt,Joachim Jankowski,Joachim Jankowski,Joachim Jankowski,Cordelia Langford,Cordelia Langford,Hugh S. Markus,Christopher G. Mathew,Robert Plomin,Anna Rautanen,Stephen Sawcer,Nilesh J. Samani,Nilesh J. Samani,Nilesh J. Samani,Richard C. Trembath,Ananth C. Viswanathan,Nicholas W. Wood,Lorna W. Harries,Lorna W. Harries,Andrew T. Hattersley,Andrew T. Hattersley,Alex S. F. Doney,Alex S. F. Doney,Helen M. Colhoun,Andrew D. Morris,Calum Sutherland,Calum Sutherland,D. G. Hardie,D. G. Hardie,Leena Peltonen,Mark I. McCarthy,Rury R. Holman,Colin N. A. Palmer,Colin N. A. Palmer,Peter Donnelly,Ewan R. Pearson +76 more
TL;DR: A genome-wide association study for glycemic response to metformin in 1,024 Scottish individuals with type 2 diabetes with replication in two cohorts including 1,783 Scottish individuals and 1,113 individuals from the UK Prospective Diabetes Study.
Journal ArticleDOI
Codimension and analytic spread
TL;DR: In this paper, the sufficiency of certain conditions on an ideal A of a local ring Q, and on a set of elements of Q generating a proper ideal G, for the ideals A and G to be analytically disjoint was established.
Journal ArticleDOI
Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: a Go-DARTS study.
Kaixin Zhou,Louise A. Donnelly,Lindsay Burch,Roger Tavendale,Alex S. F. Doney,Graham P. Leese,Andrew T. Hattersley,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Andrew D. Morris,Chim C. Lang,Colin N. A. Palmer,Ewan R. Pearson +13 more
TL;DR: It is found that patients with two copies of a loss‐of‐function allele are associated with greater response to sulfonylureas and decreased failure of therapy consistent with the pharmacokinetic role of CYP2C9.
Journal ArticleDOI
Novel phosphorylation sites of human tumour suppressor protein p53 at ser20 and thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers
Ashley L. Craig,Lindsay Burch,Borek Vojtesek,Jaroslava Mikutowska,Alastair M. Thompson,Ted R. Hupp +5 more
TL;DR: Evidence in vivo is provided for two novel phosphorylation sites within p53 at Ser(20) and Thr(18) that can affect p53 protein-protein interactions and indicate that some human cancers might have amplified one or more Ser( 20) andThr( 18) kinase signalling cascades to modulate p53 activity.