C
Ciara O’Donnell
Publications - 6
Citations - 644
Ciara O’Donnell is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 6 publications receiving 644 citations.
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Journal ArticleDOI
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
Bo Meng,Adam Abdullahi,Isabella Ferreira,Niluka Goonawardane,Akatsuki Saito,Izumi Kimura,Daichi Yamasoba,P. P. G. Gerber,Saman Fatihi,Surabhi Rathore,Samantha K. Zepeda,Guido Papa,Steven Kemp,Terumasa Ikeda,Mako Toyoda,Toong Seng Tan,Jin Kuramochi,Shigeki Mitsunaga,Takamasa Ueno,Kotaro Shirakawa,Akifumi Takaori-Kondo,Teresa Brevini,Donna L. Mallery,Oscar Charles,Stephen Baker,Gordon Dougan,Christoph Hess,Nathalie Kingston,Paul J. Lehner,Paul A. Lyons,Nick Matheson,Willem H. Ouwehand,Caroline M. Saunders,Charlotte Summers,James Thaventhiran,Mark Toshner,Michael P. Weekes,Patrick Maxwell,Ashley Shaw,Ashlea Bucke,Jo Calder,Laura Canna,Jason Domingo,Anne Elmer,Stewart Fuller,Julie Harris,Sarah Hewitt,Jane Kennet,Sherly Jose,Jenny Kourampa,Anne Meadows,Criona O’Brien,Jane Mary Price,Cherry Publico,Rebecca Rastall,Carla Ribeiro,Jane Rowlands,Valentina Ruffolo,Hugo Tordesillas,Ben Bullman,Benjamin J. Dunmore,Stefan Gräf,Joshua Hodgson,Christopher Huang,K Hunter,Emma Jones,Ekaterina Legchenko,Cecilia Cabrera Matara,Jennifer M. Martin,Federica Mescia,Ciara O’Donnell,Linda Pointon,Joy Shih,Rachel Sutcliffe,Tobias Tilly,Carmen M. Treacy,Zhen Tong,Jennifer Wood,Marta Wylot,Ariana Betancourt,Georgie Bower,Chiara Cossetti,Aloka De Sa,Maddie Epping,Stuart Fawke,Nicholas Gleadall,Richard Grenfell,Andrew Hinch,Sarah Jackson,Isobel Jarvis,Ben Krishna,Francesca L. Nice,Ommar Omarjee,Marianne Perera,Martin Potts,Nathan Richoz,Veronika Romashova,Luca Stefanucci,Mateusz Strezlecki,Lori Turner,E. D. De Bie,Katherine Bunclark,Masa Josipovic,Michael Mackay,Helen Butcher,Dan Scott Caputo,Mathew Allen. Chandler,Patrick F. Chinnery,Debbie Clapham-Riley,E Dewhurst,Christian Fernandez,Anita Furlong,Barbara J. Graves,J. Gray,Sabine Hein,Tasmin Ivers,Emma Le Gresley,Rachel Linger,Mary A Kasanicki,Rebecca King,Sara E. Meloy,Alex A. Moulton,Frances E. Muldoon,Nigel R. Ovington,Sofia Papadia,Christopher J. Penkett,Isabel Phelan,Venkatesh-Prasad Ranganath,R. Paraschiv,Abigail Sage,Jennifer G. Sambrook,Ingrid Scholtes,Katherine Schon,Hannah Stark,Kathleen Stirrups,Paul Townsend,Neil Walker,Jennifer Rose Webster,Erika P. Butlertanaka,Yurie Tanaka,Jumpei Ito,Keiya Uriu,Yusuke Kosugi,Mai Suganami,Akiko Oide,Miyabishara Yokoyama,Mika Chiba,Chihiro Motozono,Hesham Nasser,Ryo Shimizu,K. Kitazato,Haruyo Hasebe,Takashi Irie,So Nakagawa,Jiaqi Wu,Miyoko Takahashi,Takasuke Fukuhara,Kenta Shimizu,Kana Tsushima,Haruko Kubo,Yasuhiro Kazuma,Ryosuke Nomura,Yoshihito Horisawa,Kayoko Nagata,Yugo Kawai,Yohei Yanagida,Yusuke Tashiro,Kenzo Tokunaga,Seiya Ozono,Ryoko Kawabata,Nanami Morizako,Kenji Sadamasu,Hiroyuki Asakura,Mami Nagashima,Kazuhisa Yoshimura,Paul Cardenas,E. Muñoz,Veronica Barragan,Sully Márquez,Belén Prado-Vivar,Mónica Becerra-Wong,Mateo Caravajal,Gabriel Trueba,Patricio Rojas-Silva,Michelle Grunauer,Bernardo Gutierrez,Juan José Guadalupe,Juan Carlos Fernandez-Cadena,D. Andrade-Molina,Manuel E. Baldeón,Andrea Pinos,John E. Bowen,Anshu Joshi,Alexandra C. Walls,Laurelle Jackson,Darren Martin,Kenneth G. C. Smith,John S. Bradley,John A. G. Briggs,Jin W. Choi,Elo Madissoon,Kerstin B. Meyer,Petra Mlcochova,Lourdes Ceron-Gutierrez,Rainer Doffinger,Sarah A. Teichmann,Andrew J. Fisher,Matteo Samuele Pizzuto,Anna De Marco,Davide Corti,Myra Hosmillo,Joo-Hyeon Lee,Leo C. James,Lipi Thukral,David Veesler,Alex Sigal,Fotios Sampaziotis,Ian Goodfellow,Kei Sato,Ravindra K. Gupta +219 more
TL;DR: The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein this paper , which increased the evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutralizing antibodies after two doses.
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity
E. Muñoz,Veronica Barragan,Sully Márquez,-. BelénPrado,Vivar,Mateo Caravajal,Gabriel Trueba,-. PatricioRojas,Silva,Michelle Grunauer,Juan José Guadalupe,Manuel E. Baldeón,Yurie Tanaka,Terumasa Ikeda,Jumpei Ito,Izumi Kimura,Keiya,Uriu,Yusuke Kosugi,Mai Suganami,Akiko Oide,Miyabishara Yokoyama,Mika,Chiba,Chihiro Motozono,Hesham Nasser,Ryo Shimizu,Yue Yuan,K. Kitazato,Haruyo Hasebe,So Nakagawa,Miyoko Takahashi,Yasuhiro Kazuma,Ryosuke Nomura,Yoshihito Horisawa,Yohei Yanagida,Yusuke,Tashiro,Stephen J. Baker,Gordon Dougan,Christoph Hess,Nathalie Kingston,Paul J. Lehner,Paul A. Lyons,Nicholas J Matheson,Willem H. Owehand,Caroline M. Saunders,Charlotte Summers,James Thaventhiran,Mark Toshner,Michael P. Weekes,Patrick H. Maxwell,Ashley Shaw,Ashlea Bucke,Jo Calder,Laura Canna,Jason,Domingo,Anne Elmer,Stewart Fuller,Julie Harris,Sarah Hewitt,Jane Kennet,Sherly Jose,Jenny Kourampa,Anne Meadows,Criona O’Brien,Jane Mary Price,Cherry,Público,Rebecca Rastall,Carla Ribeiro,Jane Rowlands,Valentina Ruffolo,Hugo,Tordesillas,Ben Bullman,Benjamin J. Dunmore,Stuart Fawke,Stefan Gräf,Josh,Hodgson,Christopher Huang,K Hunter,Emma-Louise Jones,Ekaterina Legchenko,Cecilia Cabrera Matara,Jennifer M. Martin,Federica Mescia,Ciara O’Donnell,Linda Pointon,Joy,Shih,Rachel Sutcliffe,Tobias Tilly,Carmen M. Treacy,Zhen Wei Marcus Tong,Jennifer Wood,Marta,Wylot,Ariana Betancourt,Georgie Bower,Chiara Cossetti,Madeline,Epping,Nicholas Gleadall,Richard Grenfell,Andrew Hinch,Sarah Jackson,Isobel Jarvis,Benjamin A. Krishna,Francesca L. Nice,Ommar Omarjee,Marianne Perera,Martin,Potts,Nathan Richoz,Veronika Romashova,Luca Stefanucci,Mateusz Strezlecki,Lori,Turner,Katherine Bunclark,Masa Josipovic,Michael Mackay,John Allison,Helen Butcher,Daniela Caputo,Eleanor,Dewhurst,Anita Furlong,J. Gray,Emma,Le Gresley,Rachel Linger,Sara E. Meloy,Frances E. Muldoon,Nigel R. Ovington,Sofia Papadia,Isabel Phelan,Hannah Stark,Kathleen Stirrups,P Townsend,Neil Walker,Jennifer Webster,Ingrid Scholtes +145 more
TL;DR: The SARS-CoV-2 Omicron BA.1.1 variant emerged in 2021 1 and bears multiple spike mutations as mentioned in this paper , and has higher affinity for ACE2 compared to Delta and significant evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutralizing antibodies after two doses.
Journal ArticleDOI
The impact of the initial COVID-19 outbreak on young adults’ mental health: a longitudinal study of risk and resilience factors
Anna Maria Wiedemann,Jan Stochl,Jessica Fritz,Junaid Bhatti,Roxanne Hook,Raymond Francis Dolan,Ian Goodyer,Peter Fonagy,Peter J. H. Jones,Michael Moutoussis,Tobias U. Hauser,Sharon Neufeld,Rafael Romero-Garcia,Michelle C. St Clair,Petra E. Vértes,Kirstie Whitaker,Becky Inkster,Gita Prabhu,Cinly Ooi,Umar Toseeb,Barry Widmer,Laura Villis,A. Alrumaithi,S. M. Birt,Aislinn Bowler,Kalia Cleridou,Hina Dadabhoy,Emma Louise Davies,Ashlyn Firkins,Sian Rachel Granville,Elizabeth Harding,Alexandra Hopkins,Dan Isaacs,Janchai King,Danae Kokorikou,Christina Maurice,Cleo McIntosh,Jessica Memarzia,Harriet Mills,Ciara O’Donnell,Sara Pantaleone,Jenny L. Scott,Beatrice Kiddle,Ela Polek,Pasco Fearon,John Suckling,Anne-Laura van Harmelen,Rogier A. Kievit,Samuel J. Chamberlain,Richard A. I. Bethlehem,Ian M. Goodyer,Raymond J. Dolan,Edward T. Bullmore,Samuel R. Chamberlain,Jesus Perez,Peter B. Jones +55 more
TL;DR: In this paper , the effects of COVID-19 on mental health include prospective markers of risk and resilience necessary to understand and mitigate the combined impacts of the pandemic, lockdowns, and other societal responses.
Journal ArticleDOI
Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease
Marta Vicente-Rodríguez,Renzo Mancuso,Alba Peris-Yague,Camilla Simmons,Dominika Wlazly,AM Dickinson,Andrea Foster,Clare Knight,Claire A Leckey,Paul Morgan,Angharad R. Morgan,Caroline O’Hagan,Samuel Touchard,Shahid M. Khan,Phil Murphy,Christine P. Parker,Jai Rajendra Patel,Jill C. Richardson,Paul Acton,Nigel E. Austin,Anindya Bhattacharya,Nick Carruthers,P. de Boer,Wayne C. Drevets,John Isaac,Declan N.C. Jones,John Kemp,Hartmuth C. Kolb,Jeff Nye,Gayle M. Wittenberg,Gareth J. Barker,Anna Michaylovna Bogdanova,H. J. Byrom,Annamaria Cattaneo,Daniela Enache,Tony Gee,Caitlin Hastings,Melisa Kose,Giulia Lombardo,Nicole Mariani,Anna McLaughlin,Valeria Mondelli,Maria A. Nettis,Naghmeh Nikkheslat,Carmine M. Pariante,K. Randall,Julia Schubert,Luca Sforzini,Hannah Sheridan,Nisha Kumari Singh,V. Van Loo,Mattia Veronese,Toby Ryan Wood,Courtney Worrell,Zuzanna Zajkowska,Brian Campbell,Jan Egebjerg,Hans Olof Alexander Eriksson,Francois Gastambide,Karen H. Adams,Ross Jeggo,Thomas Moeller,Bob Nelson,Niels Plath,Christian von Thomsen,Jan Torleif Pederson,Stevin H. Zorn,Catherine Deith,Scott Farmer,J R Mcclean,Andrew D. McPherson,Nagore Penandes,Paul Scouller,Murray Sutherland,M J Attenburrow,Jithen Benjamin,Helen Jones,Francisca Mada,Akintayo Oladejo,Katy Smith,Rita J. Balice-Gordon,Brendon Binneman,James M. Duerr,Terence Fullerton,V V Nishanth Goli,Zoe Pamela Hughes,Justin R. Piro,Tarek A. Samad,Jonathan R. Sporn,Liz Hoskins,C. Kohn,Lauren Wilcock,Franklin I. Aigbirhio,Junaid Bhatti,Edward T. Bullmore,Samuel J. Chamberlain,Marta M Correia,Anna L. Crofts,Tim D. Fryer,M. Graves,Alex Hatton,Manfred G. Kitzbichler,Mary-Ellen Lynall,Christina Maurice,Ciara O’Donnell,Linda Pointon,Peter St. George Hyslop,Lorinda Turner,Petra E. Vértes,Barry Widmer,Guy O. Williams,Jonathan Cavanagh,Alison McColl,Robin Shaw,Erik Boddeke,Alison L. Baird,Stuart Clare,Philip A. Cowen,I-Shu (Dante) Huang,Samuel Hurley,Alejo J. Nevado-Holgado,Elena M. Ribe,Anviti Vyas,Laura Winchester,Madeleine Cleal,Diego Gomez-Nicola,Hugh Perry,Mara Cercignani,Charlotte Clarke,Alessandro Colasanti,Neil A. Harrison,Rosemary Murray,Jason O’Connor,H.J. Mount,V. Hugh Perry,Federico Turkheimer,Simon Lovestone,Christine A. Parker,Diana Cash +138 more
TL;DR: In this paper , a selective CSF1R inhibitor, JNJ-40346527 (JNJ527), attenuated the disease-dependent increase in TSPO signal, particularly in the dentate gyrus of the hippocampus.
Journal ArticleDOI
Reducing the treatment burden of keratinocyte cancers requiring referral to plastic surgery: Lessons from lockdown
TL;DR: In this paper , a revised interspecialty pathway was proposed to reduce the time-to-treatment completion (days) and treatment burden (defined as total healthcare encounter days) for patients with keratinocyte cancer.