Francesca L. Nice

TL;DR: Somatic mutations in the endoplasmic reticulum chaperone CALR were found in a majority of patients with myeloproliferative neoplasms with nonmutated JAK2, a finding consistent with its role as an initiating mutation in some patients.

TL;DR: The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein this paper , which increased the evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutralizing antibodies after two doses.

TL;DR: Comprehensive genomic characterization identified distinct genetic subgroups and provided a classification of myeloproliferative neoplasms on the basis of causal biologic mechanisms and may support the treatment of patients with myelofibrosis.

TL;DR: In MPN patients, mutations in JAK2, CALR and MPL are found in the majority of myeloproliferative neoplasms but many patients also harbor somatic mutations in epigenetic regulators of DNA methylation or chromatin structure.

TL;DR: The SARS-CoV-2 Omicron BA.1.1 variant emerged in 2021 1 and bears multiple spike mutations as mentioned in this paper , and has higher affinity for ACE2 compared to Delta and significant evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutralizing antibodies after two doses.