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Seiya Ozono
Researcher at National Institutes of Health
Publications - 24
Citations - 1952
Seiya Ozono is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 14 publications receiving 321 citations. Previous affiliations of Seiya Ozono include University of Yamanashi.
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Journal ArticleDOI
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
Bo Meng,Adam Abdullahi,Isabella Ferreira,Niluka Goonawardane,Akatsuki Saito,Izumi Kimura,Daichi Yamasoba,P. P. G. Gerber,Saman Fatihi,Surabhi Rathore,Samantha K. Zepeda,Guido Papa,Steven Kemp,Terumasa Ikeda,Mako Toyoda,Toong Seng Tan,Jin Kuramochi,Shigeki Mitsunaga,Takamasa Ueno,Kotaro Shirakawa,Akifumi Takaori-Kondo,Teresa Brevini,Donna L. Mallery,Oscar Charles,Stephen Baker,Gordon Dougan,Christoph Hess,Nathalie Kingston,Paul J. Lehner,Paul A. Lyons,Nick Matheson,Willem H. Ouwehand,Caroline M. Saunders,Charlotte Summers,James Thaventhiran,Mark Toshner,Michael P. Weekes,Patrick Maxwell,Ashley Shaw,Ashlea Bucke,Jo Calder,Laura Canna,Jason Domingo,Anne Elmer,Stewart Fuller,Julie Harris,Sarah Hewitt,Jane Kennet,Sherly Jose,Jenny Kourampa,Anne Meadows,Criona O’Brien,Jane Mary Price,Cherry Publico,Rebecca Rastall,Carla Ribeiro,Jane Rowlands,Valentina Ruffolo,Hugo Tordesillas,Ben Bullman,Benjamin J. Dunmore,Stefan Gräf,Joshua Hodgson,Christopher Huang,K Hunter,Emma Jones,Ekaterina Legchenko,Cecilia Cabrera Matara,Jennifer M. Martin,Federica Mescia,Ciara O’Donnell,Linda Pointon,Joy Shih,Rachel Sutcliffe,Tobias Tilly,Carmen M. Treacy,Zhen Tong,Jennifer Wood,Marta Wylot,Ariana Betancourt,Georgie Bower,Chiara Cossetti,Aloka De Sa,Maddie Epping,Stuart Fawke,Nicholas Gleadall,Richard Grenfell,Andrew Hinch,Sarah Jackson,Isobel Jarvis,Ben Krishna,Francesca L. Nice,Ommar Omarjee,Marianne Perera,Martin Potts,Nathan Richoz,Veronika Romashova,Luca Stefanucci,Mateusz Strezlecki,Lori Turner,E. D. De Bie,Katherine Bunclark,Masa Josipovic,Michael Mackay,Helen Butcher,Dan Scott Caputo,Mathew Allen. Chandler,Patrick F. Chinnery,Debbie Clapham-Riley,E Dewhurst,Christian Fernandez,Anita Furlong,Barbara J. Graves,J. Gray,Sabine Hein,Tasmin Ivers,Emma Le Gresley,Rachel Linger,Mary A Kasanicki,Rebecca King,Sara E. Meloy,Alex A. Moulton,Frances E. Muldoon,Nigel R. Ovington,Sofia Papadia,Christopher J. Penkett,Isabel Phelan,Venkatesh-Prasad Ranganath,R. Paraschiv,Abigail Sage,Jennifer G. Sambrook,Ingrid Scholtes,Katherine Schon,Hannah Stark,Kathleen Stirrups,Paul Townsend,Neil Walker,Jennifer Rose Webster,Erika P. Butlertanaka,Yurie Tanaka,Jumpei Ito,Keiya Uriu,Yusuke Kosugi,Mai Suganami,Akiko Oide,Miyabishara Yokoyama,Mika Chiba,Chihiro Motozono,Hesham Nasser,Ryo Shimizu,K. Kitazato,Haruyo Hasebe,Takashi Irie,So Nakagawa,Jiaqi Wu,Miyoko Takahashi,Takasuke Fukuhara,Kenta Shimizu,Kana Tsushima,Haruko Kubo,Yasuhiro Kazuma,Ryosuke Nomura,Yoshihito Horisawa,Kayoko Nagata,Yugo Kawai,Yohei Yanagida,Yusuke Tashiro,Kenzo Tokunaga,Seiya Ozono,Ryoko Kawabata,Nanami Morizako,Kenji Sadamasu,Hiroyuki Asakura,Mami Nagashima,Kazuhisa Yoshimura,Paul Cardenas,E. Muñoz,Veronica Barragan,Sully Márquez,Belén Prado-Vivar,Mónica Becerra-Wong,Mateo Caravajal,Gabriel Trueba,Patricio Rojas-Silva,Michelle Grunauer,Bernardo Gutierrez,Juan José Guadalupe,Juan Carlos Fernandez-Cadena,D. Andrade-Molina,Manuel E. Baldeón,Andrea Pinos,John E. Bowen,Anshu Joshi,Alexandra C. Walls,Laurelle Jackson,Darren Martin,Kenneth G. C. Smith,John S. Bradley,John A. G. Briggs,Jin W. Choi,Elo Madissoon,Kerstin B. Meyer,Petra Mlcochova,Lourdes Ceron-Gutierrez,Rainer Doffinger,Sarah A. Teichmann,Andrew J. Fisher,Matteo Samuele Pizzuto,Anna De Marco,Davide Corti,Myra Hosmillo,Joo-Hyeon Lee,Leo C. James,Lipi Thukral,David Veesler,Alex Sigal,Fotios Sampaziotis,Ian Goodfellow,Kei Sato,Ravindra K. Gupta +219 more
TL;DR: The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein this paper , which increased the evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutralizing antibodies after two doses.
Journal ArticleDOI
Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant
Rigel Suzuki,Daichi Yamasoba,Izumi Kimura,Lei Wang,Mai Kishimoto,Jumpei Ito,Yuhei Morioka,Naganori Nao Nao,Hesham Nasser,Keiya Uriu,Yusuke Kosugi,Masumi Tsuda,Yasuko Orba,Michihito Sasaki,Ryo Shimizu,Ryoko Kawabata,Kumiko Yoshimatsu,Hiroyuki Asakura,Mami Nagashima,Kenji Sadamasu,Kazuhisa Yoshimura,Mai Suganami,Akiko Oide,Mika Chiba,H. Ito,Tomokazu Tamura,Kana Tsushima,Haruko Kubo,Zannatul Ferdous,Hiromi Mouri,Miki Iida,Keiko Kasahara,Koshiro Tabata,Mariko Ishizuka,Asako Shigeno,Kenzo Tokunaga,Seiya Ozono,Iwao Yoshida,So Nakagawa,Jiaqi Wu,Miyoko Takahashi,Atsushi Kaneda,Motoaki Seki,Ryoji Fujiki,Bahityar Rahmutulla Nawai,Yutaka Suzuki,Yukie Kashima,Kazumi Abe,Kiyomi Imamura,Kotaro Shirakawa,Akifumi Takaori-Kondo,Yasuhiro Kazuma,Ryosuke Nomura,Yoshihito Horisawa,Kayoko Nagata,Yugo Kawai,Yohei Yanagida,Yusuke Tashiro,Otowa Takahashi,K. Kitazato,Haruyo Hasebe,Chihiro Motozono,Mako Toyoda,Toong Seng Tan,Isaac Ngare,Takamasa Ueno,Akatsuki Saito,Erika P. Butlertanaka,Yurie Tanaka,Nanami Morizako,Hirofumi Sawa,Terumasa Ikeda,Takashi Irie,Keita Matsuno,Shinya Tanaka,Takasuke Fukuhara,Kei Sato +76 more
TL;DR: The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern as mentioned in this paper , and statistical modelling suggests that OmicRON has spread more rapidly than the Delta variant in several countries including South Africa.
Journal ArticleDOI
SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity.
Seiya Ozono,Seiya Ozono,Yanzhao Zhang,Hirotaka Ode,Kaori Sano,Toong Seng Tan,Kazuo Imai,Kazuyasu Miyoshi,Satoshi Kishigami,Takamasa Ueno,Yasumasa Iwatani,Tadaki Suzuki,Kenzo Tokunaga +12 more
TL;DR: In this paper, the authors show that naturally occurring S mutations can reduce or enhance cell entry via ACE2 and TMPRSS2, and conclude that the D614G mutation increases cell entry by acquiring higher affinity to ACE2 while maintaining neutralization susceptibility.
Journal ArticleDOI
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2
Ryuta Uraki,Maki Kiso,Shun Iida,Masaki Imai,Emi Takashita,Makoto Kuroda,Peter Halfmann,Samantha Loeber,Tadashi Maemura,Seiya Yamayoshi,Seiichiro Fujisaki,Zhongde Wang,Mutsumi Ito,Michiko Ujie,Kiyoko Iwatsuki-Horimoto,Yuri Furusawa,R. Wright,Zhenlu Chong,Seiya Ozono,Atsuhiro Yasuhara,Hiroshi Ueki,Yuko Sakai-Tagawa,Rongxiu Li,Yanan Liu,Deanna Larson,Michiko Koga,Takeya Tsutsumi,Eisuke Adachi,Makoto Saito,Shinya Yamamoto,Masao Hagihara,Keiko Mitamura,Tetsuro Sato,Masayuki Hojo,Shin-ichiro Hattori,Kenji Maeda,Riccardo Valdez,Pamela E. Bennett-Baker,Zijin Chu,Dawson Davis,Theresa Kowalski-Dobson,Ashley Eckard,Carmen Gherasim,Wolf Gremel,Kathy Lindsey,David M Manthei,A. Meyers,Julio Zuniga Moya,Aaron Rico,Emily Stoneman,Victoria Le Blanc,Savanna Sneeringer,Lauren Warsinske,Moe Okuda,Jurika Murakami,C. Duong,Sucheta Godbole,Daniel C. Douek,Ken Maeda,Shinji Watanabe,Aubree Gordon,Norio Ohmagari,Hiroshi Yotsuyanagi,Michael S. Diamond,Hideki Hasegawa,Hiroaki Mitsuya,Tadaki Suzuki,Yoshihiro Kawaoka +67 more
TL;DR: In this article , the authors evaluated the replicative ability and pathogenicity of authentic infectious BA.2 isolates in immunocompetent and human ACE2-expressing mice and hamsters.
Journal ArticleDOI
SARS-CoV-2 B.1.617 mutations L452 and E484Q are not synergistic for antibody evasion.
Isabella Ferreira,Steven Kemp,Rawlings Datir,Akatsuki Saito,Bo Meng,Partha Rakshit,Akifumi Takaori-Kondo,Yusuke Kosugi,Keiya Uriu,Izumi Kimura,Kotaro Shirakawa,Adam Abdullahi,Anurag Agarwal,Seiya Ozono,Kenzo Tokunaga,Kei Sato,Ravindra K. Gupta +16 more
TL;DR: This paper showed that spike bearing L452R and E484Q confers modestly reduced sensitivity to BNT162b2 mRNA vaccine-elicited antibodies following either first or second dose.