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Claire E. Stewart
Researcher at Liverpool John Moores University
Publications - 159
Citations - 6842
Claire E. Stewart is an academic researcher from Liverpool John Moores University. The author has contributed to research in topics: Skeletal muscle & Myocyte. The author has an hindex of 44, co-authored 145 publications receiving 5987 citations. Previous affiliations of Claire E. Stewart include Washington University in St. Louis & Oregon Health & Science University.
Papers
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Journal ArticleDOI
Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors
Claire E. Stewart,Peter Rotwein +1 more
TL;DR: The structures and functions of the two IGF receptors are discussed, the actions of the six IGFBPs are outlined, and recent studies highlighting essential roles for components of the IGF system in the growth and development of the embryo and fetus are interpreted.
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Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality.
TL;DR: Results show that Igf2r is paternally imprinted and reveal that the receptor is crucial for regulating normal fetal growth, circulating levels of IGF2, and heart development.
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Insulin-like growth factor-II is an autocrine survival factor for differentiating myoblasts.
Claire E. Stewart,Peter Rotwein +1 more
TL;DR: The results define a novel system for studying apoptotic cell death and its prevention by growth factors, underscore the importance of IGF action in minimizing inappropriate cell death, and indicate that shared signal transduction pathways may mediate myoblast survival in vitro.
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Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy
Robert A. Seaborne,Robert A. Seaborne,Juliette A. Strauss,Matthew Cocks,Sam O. Shepherd,Thomas D. O'Brien,Ken A. van Someren,Phillip G. Bell,Chris Murgatroyd,James P. Morton,Claire E. Stewart,Adam P. Sharples,Adam P. Sharples +12 more
TL;DR: GRIK2, TRAF1, BICC1, STAG1 were epigenetically sensitive to acute exercise demonstrating hypomethylation after a single bout of resistance exercise that was maintained 22 weeks later with the largest increase in gene expression and muscle mass after reloading.
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Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss.
Richard Kirwan,Deaglan McCullough,Thomas Butler,Fátima Pérez de Heredia,Ian G Davies,Claire E. Stewart +5 more
TL;DR: In this paper, the authors review mechanisms of sarcopenia and their relation to the current data on the effects of COVID-19 confinement on physical activity, dietary habits, sleep, and stress as well as extended bed rest due to COVID19 hospitalization.