Journal ArticleDOI
Neonatal adaptive immunity comes of age
TLDR
This review focuses on the new understanding in mice and, where it is clear that related phenomena occur, in humans.Abstract:
The past decade has brought great strides in our understanding of adaptive immunity in neonatal mice. Although poor immune responses are commonly observed, it is now clear that mature function can be achieved by all arms of the adaptive immune system. An ever-increasing body of evidence indicates that the neonatal period of life is a unique developmental stage in which responses are highly plastic and dependent on the conditions of antigen exposure. This review focuses on our new understanding in mice and, where it is clear that related phenomena occur, in humans.read more
Citations
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Adverse childhood experiences, allostasis, allostatic load, and age-related disease
Andrea Danese,Bruce S. McEwen +1 more
TL;DR: Adverse childhood experiences induce significant biological changes in children (biological embedding), modifying the maturation and the operating balance of allostatic systems, and can exert long-term effects on biological aging and health.
Journal ArticleDOI
Innate immunity of the newborn: basic mechanisms and clinical correlates
TL;DR: Invention of innate immunity in newborns is described and how this knowledge might be used to prevent and treat infection in this vulnerable population is discussed.
Journal ArticleDOI
IgG Placental Transfer in Healthy and Pathological Pregnancies
Patricia Palmeira,Camila Quinello,Ana Lúcia Silveira-Lessa,Cláudia Augusta Zago,Magda Carneiro-Sampaio +4 more
TL;DR: There is evidence that IgG transfer depends on the following: (i) maternal levels of total IgG and specific antibodies, (ii) gestational age, (iii) placental integrity, (iv) IgG subclass, and (v) nature of antigen, being more intense for thymus-dependent ones.
Journal ArticleDOI
Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology
TL;DR: In this review, the complete picture from epidemiology and virology to clinical impact and immunology is explored, finding that both the virus and the immune response contribute to damage to the lungs and subsequent disease, and therefore, any prevention or treatment needs to address both of these factors.
Journal ArticleDOI
Macrophages are required for neonatal heart regeneration
Arin B. Aurora,Enzo R. Porrello,Wei Tan,Ahmed I. Mahmoud,Joseph A. Hill,Rhonda Bassel-Duby,Hesham A. Sadek,Eric N. Olson +7 more
TL;DR: It is suggested that macrophages provide necessary signals to drive angiogenesis and regeneration of the neonatal mouse heart, and modulating inflammation may provide a key therapeutic strategy to support heart regeneration.
References
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TL;DR: Progress in understanding some aspects of this process in the mouse bone marrow is reviewed, focusing on delineation of the earliest stages of commitment, on pre-B cell receptor selection, and B cell tolerance during the immature-to-mature B cell transition.
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Carine Asselin-Paturel,Andre Boonstra,Marc Dalod,Isabelle Durand,Nadia Yessaad,Colette Dezutter-Dambuyant,Alain Vicari,Anne O'Garra,Christine A. Biron,Francine Brière,Giorgio Trinchieri +10 more
TL;DR: It is shown that mouse interferon-α–producing cells (mIPCs) are a unique subset of immature antigen-presenting cells (APCs) that secrete IFN-α upon stimulation with viruses and interleukin 12 (IL-12) in response to viruses and CpG oligodeoxynucleotides, but not bacterial products.
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Marginal Zone and B1 B Cells Unite in the Early Response against T-Independent Blood-Borne Particulate Antigens
TL;DR: Splenic MZ and B1 B cells endowed with a "natural memory" provide a bridge between the very early innate and the later appearing adaptive immune response.
Journal ArticleDOI
Development of allergen-specific T-cell memory in atopic and normal children
TL;DR: The continuation of fetal allergen-specific Th2 responses during infancy is a defining feature of the inductive phase of atopic disease, and is associated with decreased capacity for production of the Th1 cytokine interferon y by atopic neonates.