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Xintian You
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 14
Citations - 2613
Xintian You is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: RNA & Gene silencing. The author has an hindex of 11, co-authored 14 publications receiving 2141 citations. Previous affiliations of Xintian You include Zuse Institute Berlin.
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Journal ArticleDOI
Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity
Xintian You,Irena Vlatkovic,Ana Babic,Tristan J. Will,Irina Epstein,Georgi Tushev,Güney Akbalik,Mantian Wang,Caspar Glock,Claudia Quedenau,Xi Wang,Jingyi Hou,Hongyu Liu,Wei Sun,Sivakumar Sambandan,Tao Chen,Erin M. Schuman,Wei Chen +17 more
TL;DR: The data indicate that brain circRNAs are positioned to respond to and regulate synaptic function and exhibited substantial up- or downregulation following a homeostatic downscaling of neuronal activity.
Journal ArticleDOI
Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth
Katharina M. Michalik,Xintian You,Yosif Manavski,Anuradha Doddaballapur,Martin Zörnig,Thomas Braun,David John,Yuliya Ponomareva,Wei Chen,Shizuka Uchida,Reinier A. Boon,Stefanie Dimmeler +11 more
TL;DR: Silencing of MALAT1 tips the balance from a proliferative to a migratory endothelial cell phenotype in vitro, and its genetic deletion or pharmacological inhibition reduces vascular growth in vivo.
Journal ArticleDOI
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation
Konstantinos Stellos,Aikaterini Gatsiou,Kimon Stamatelopoulos,Ljubica Perisic Matic,David John,Federica Francesca Lunella,Nicolas Jaé,Oliver Rossbach,Carolin Amrhein,Frangiska Sigala,Reinier A. Boon,Boris Fürtig,Yosif Manavski,Xintian You,Shizuka Uchida,Till Keller,Jes Niels Boeckel,Anders Franco-Cereceda,Lars Maegdefessel,Wei Chen,Harald Schwalbe,Albrecht Bindereif,Per Eriksson,Ulf Hedin,Andreas M. Zeiher,Stefanie Dimmeler +25 more
TL;DR: It is shown that cathepsin S mRNA (CTSS), which encodes a cysteine protease associated with angiogenesis and atherosclerosis, is highly edited in human endothelial cells, revealing a previously unrecognized role of RNA editing in gene expression in human atherosclerotic vascular diseases.
Journal ArticleDOI
Laminar Shear Stress Inhibits Endothelial Cell Metabolism via KLF2-Mediated Repression of PFKFB3
Anuradha Doddaballapur,Katharina M. Michalik,Yosif Manavski,Tina Lucas,Riekelt H. Houtkooper,Xintian You,Wei Chen,Andreas M. Zeiher,Michael Potente,Stefanie Dimmeler,Reinier A. Boon +10 more
TL;DR: In this paper, the authors showed that shear stress exposure reduced glucose uptake and mitochondrial content in endothelium and showed that KLF2 overexpression recapitulates the inhibitory effects on endothelial glycolysis elicited by laminar flow.
Journal ArticleDOI
Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell
Sudhir Gopal Tattikota,Thomas Rathjen,Sarah J McAnulty,Hans-Hermann Wessels,Ildem Akerman,Martijn van de Bunt,Jean Hausser,Jonathan L.S. Esguerra,Anne Musahl,Amit Kumar Pandey,Xintian You,Wei Chen,Pedro Luis Herrera,Paul Johnson,Paul Johnson,Dónal O'Carroll,Lena Eliasson,Mihaela Zavolan,Anna L. Gloyn,Anna L. Gloyn,Jorge Ferrer,Jorge Ferrer,Ruby Shalom-Feuerstein,Daniel Aberdam,Daniel Aberdam,Matthew N. Poy +25 more
TL;DR: It is reported that miR-184 is silenced in the pancreatic islets of insulin-resistant mouse models and type 2 diabetic human subjects and administration of a ketogenic diet to ob/ob mice rescued insulin sensitivity and miR -184 expression and restored Ago2 and β cell mass.