Claudio Alarcón

TL;DR: It is shown that restoring the expression of these microRNAs in malignant cells suppresses lung and bone metastasis by human cancer cells in vivo, and miR-126 restoration reduces overall tumour growth and proliferation, whereasmiR-335 inhibits metastatic cell invasion.

TL;DR: A subsequent agonist-induced phosphorylation that plays a central dual role in Smad transcriptional activation and turnover is identified that is an integral part of canonical BMP and TGF-beta pathways.

TL;DR: It is shown that linker phosphorylation restricts Smad1 activity by enabling Smad2 recognition by the HECT-domain ubiquitin ligase Smurf1, and the interplay between linkerosphorylation, Smirf-dependent ubiquitination, and nucleoporin exclusion enables regulation of BMP action by diverse signals and biological contexts.

TL;DR: Previously identified as a regulator of renal sodium channels, Nedd4L is shown here to play a broader role as a general modulator of Smad turnover during TGF-beta signal transduction.

TL;DR: It is suggested that C/EBPbeta plays a key role in the coordination of TGFbeta cytostatic gene responses, and its malfunction may trigger evasion of these responses in breast cancer.