Q
Qiaoran Xi
Researcher at Tsinghua University
Publications - 35
Citations - 2729
Qiaoran Xi is an academic researcher from Tsinghua University. The author has contributed to research in topics: SMAD & Biology. The author has an hindex of 16, co-authored 28 publications receiving 2397 citations. Previous affiliations of Qiaoran Xi include Memorial Sloan Kettering Cancer Center & New York University.
Papers
More filters
Journal ArticleDOI
Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways
Claudio Alarcón,Alexia Ileana Zaromytidou,Qiaoran Xi,Sheng Gao,Jianzhong Yu,Sho Fujisawa,Afsar Barlas,Alexandria N. Miller,Katia Manova-Todorova,Maria J. Macias,Gopal P. Sapkota,Duojia Pan,Duojia Pan,Joan Massagué,Joan Massagué +14 more
TL;DR: A subsequent agonist-induced phosphorylation that plays a central dual role in Smad transcriptional activation and turnover is identified that is an integral part of canonical BMP and TGF-beta pathways.
Journal ArticleDOI
Recurrently deregulated lncRNAs in hepatocellular carcinoma.
Yang Yang,Lei Chen,Jin Gu,Hongquan Zhang,Jiapei Yuan,Qiuyu Lian,Guishuai Lv,Siqi Wang,Yao-Wen Wu,Yucheng T. Yang,Dong Wang,Yang Liu,Jing Tang,Guijuan Luo,Yang Li,Long Hu,Xinbao Sun,Dong Wang,Mingzhou Guo,Qiaoran Xi,Jianzhong Xi,Hongyang Wang,Michael Q. Zhang,Michael Q. Zhang,Zhi Lu +24 more
TL;DR: By analysing 60 clinical samples' RNA-seq data from 20 HCC patients, 8,603 candidate lncRNAs are identified and characterized and further validated using RNAi-based loss-of-function assays provide a valuable resource of functional lnc RNAs and biomarkers associated with HCC tumorigenesis and metastasis.
Journal ArticleDOI
A Poised Chromatin Platform for TGF-β Access to Master Regulators
Qiaoran Xi,Zhanxin Wang,Alexia Ileana Zaromytidou,Xiang Zhang,Lai Fong Chow-Tsang,Jing X. Liu,Hyesoo Kim,Afsar Barlas,Katia Manova-Todorova,Vesa Kaartinen,Lorenz Studer,Willie Mark,Dinshaw J. Patel,Joan Massagué,Joan Massagué +14 more
TL;DR: It is reported that nodal TGF-β signals use the poised histone mark H3K9me3 to trigger differentiation of mammalian embryonic stem cells to switch master regulators of stem cell differentiation from the poised to the active state.
Journal ArticleDOI
A Smad action turnover switch operated by WW domain readers of a phosphoserine code
Eric Aragón,Nina Goerner,Alexia-Ileana Zaromytidou,Qiaoran Xi,Albert Escobedo,Joan Massagué,Maria J. Macias +6 more
TL;DR: A Smad phosphoserine code and a set of WW domain code readers provide an efficient solution to the problem of coupling TGF-β signal delivery to turnover of the Smad signal transducers.
Journal ArticleDOI
Selective degradation of AU-rich mRNAs promoted by the p37 AUF1 protein isoform.
TL;DR: Data indicate that the p37 AUF1 isoform and, to some extent, the p40 isoform are limiting factors that facilitate rapid decay of AU-rich mRNAs.