D
David Padua
Researcher at University of California, Los Angeles
Publications - 22
Citations - 4356
David Padua is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Long non-coding RNA & Inflammatory bowel disease. The author has an hindex of 11, co-authored 20 publications receiving 3993 citations. Previous affiliations of David Padua include Memorial Sloan Kettering Cancer Center & Veterans Health Administration.
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Journal ArticleDOI
Endogenous human microRNAs that suppress breast cancer metastasis
Sohail F. Tavazoie,Claudio Alarcón,Thordur Oskarsson,David Padua,Qiongqing Wang,Paula D. Bos,William L. Gerald,Joan Massagué +7 more
TL;DR: It is shown that restoring the expression of these microRNAs in malignant cells suppresses lung and bone metastasis by human cancer cells in vivo, and miR-126 restoration reduces overall tumour growth and proliferation, whereasmiR-335 inhibits metastatic cell invasion.
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TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4
David Padua,Xiang Zhang,Qiongqing Wang,Cristina Nadal,William L. Gerald,Roger R. Gomis,Joan Massagué +6 more
TL;DR: It is shown that the cytokine TGFbeta in the breast tumor microenvironment primes cancer cells for metastasis to the lungs, central to this process is the induction of angiopoietin-like 4 (ANGPTL4) by TGF beta via the Smad signaling pathway.
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Roles of TGFβ in metastasis
David Padua,Joan Massagué +1 more
TL;DR: The TGF-β signaling pathway is conserved from flies to humans and has been shown to regulate such diverse processes as cell proliferation, differentiation, motility, adhesion, organization, and programmed cell death as mentioned in this paper.
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Lung metastasis genes couple breast tumor size and metastatic spread
Andy J. Minn,Gaorav P. Gupta,David Padua,Paula D. Bos,Don X. Nguyen,Dimitry S.A. Nuyten,Bas Kreike,Yi Zhang,Yixin Wang,Hemant Ishwaran,John A. Foekens,Marc J. van de Vijver,Joan Massagué +12 more
TL;DR: The mechanistic linkage between metastasis gene expression, accelerated tumor growth, and likelihood of metastatic recurrence provided by the LMS may help to explain observations of prognostic gene signatures in primary cancer and how tumor growth can both lead to metastasis and be a marker for cells destined to metastasize.
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Altered brain-gut axis in autism: Comorbidity or causative mechanisms?
TL;DR: Evidence in a model involving maternal infection, that is characterized by alterations in behavior, gut physiology, microbial composition, and related metabolite profile, suggests a possible benefit of probiotic treatment on several of the observed abnormal behaviors.