Cong Han

TL;DR: It is determined that d-alanine:d-alanin ligase (Ddl) is another new target for quercetin and apigenin, and this work is expected to help shed more light on the potential antibacterial mechanism of flavonoids.

TL;DR: A new aroE gene encoding SDH from Helicobacter’s strain SS1 is identified and expected to favor better understanding the features of SDH and provide useful information for the development of novel antibiotics to treat H.’pylori‐associated infection.

TL;DR: The results demonstrated that the strategy, reverse docking in conjunction with bioassay and structural biology, is effective and can be used as a complementary approach of functional genomics and chemical biology in target identification.

TL;DR: Very high resolution provides the first view of the atomic detail of the interface between the core trimeric cupredoxin structure of CuNiR and the tethered cytochrome c domain that allows the enzyme to function as an effective self-electron transfer system where the donor and acceptor proteins are fused together by genomic acquisition for functional advantage.

TL;DR: Crystallographic structures provide a clear structural rationale for these observations, including restoration of the proton delivery via a significant movement of the loop connecting the T1Cu ligands Cys130 and His139 that occurs on binding of nitrite.