D
Dalei Wu
Researcher at Shandong University
Publications - 44
Citations - 2372
Dalei Wu is an academic researcher from Shandong University. The author has contributed to research in topics: Aryl hydrocarbon receptor & Medicine. The author has an hindex of 23, co-authored 37 publications receiving 1795 citations. Previous affiliations of Dalei Wu include Discovery Institute & University of California, Berkeley.
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Journal ArticleDOI
Structural integration in hypoxia-inducible factors
TL;DR: In this paper, the crystal structures for each of mouse HIF-2α-ARNT and HIF1α -ARNT heterodimers in states that include bound small molecules and their hypoxia response element are described.
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Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans
Susan H. Smith,Channa K Jayawickreme,David J. Rickard,Edwige Nicodeme,Thi Bui,Cathy Simmons,Christine M. Coquery,Jessica Neil,William M. Pryor,David L. Mayhew,Deepak K. Rajpal,Katrina L. Creech,Sylvia Furst,James Lee,Dalei Wu,Fraydoon Rastinejad,Timothy M. Willson,Fabrice Viviani,David C. Morris,John T. Moore,Javier Cote-Sierra +20 more
TL;DR: These studies identify tapinarof as an AhR agonist and confirm that its efficacy is dependent on AhR.
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Cross-talk between Aryl Hydrocarbon Receptor and the Inflammatory Response: A ROLE FOR NUCLEAR FACTOR-κB*
Christoph F.A. Vogel,Elaine M. Khan,Patrick S.C. Leung,M. Eric Gershwin,W. L. William Chang,Dalei Wu,Thomas Haarmann-Stemmann,Alexander Hoffmann,Michael S. Denison +8 more
TL;DR: It is shown for the first time that NF-κB RelA is a critical component regulating the expression of AhR and the induction ofAhR-dependent gene expression in immune cells illustrating the interaction of Ahr and NF-σκB signaling.
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Multidomain integration in the structure of the HNF-4α nuclear receptor complex
TL;DR: The findings suggest that unique quaternary folds and interdomain connections in NRs could be exploited by small-molecule allosteric modulators that affect distal functions in these polypeptides.
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d-Alanine:d-alanine ligase as a new target for the flavonoids quercetin and apigenin
TL;DR: It is determined that d-alanine:d-alanin ligase (Ddl) is another new target for quercetin and apigenin, and this work is expected to help shed more light on the potential antibacterial mechanism of flavonoids.