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Connie M. Krawczyk
Researcher at McGill University
Publications - 60
Citations - 7427
Connie M. Krawczyk is an academic researcher from McGill University. The author has contributed to research in topics: T cell & Biology. The author has an hindex of 31, co-authored 45 publications receiving 6356 citations. Previous affiliations of Connie M. Krawczyk include Austrian Academy of Sciences & Van Andel Institute.
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Journal ArticleDOI
Control of Effector CD8+ T Cell Function by the Transcription Factor Eomesodermin
Erika L. Pearce,Alan C. Mullen,Gislâine A. Martins,Connie M. Krawczyk,Anne S. Hutchins,Valerie P. Zediak,Monica Banica,Catherine B. DiCioccio,Darrick A. Gross,Chai An Mao,Hao Shen,Nezih Cereb,Soo Young Yang,Tullia Lindsten,Janet Rossant,Christopher A. Hunter,Steven L. Reiner +16 more
TL;DR: It is suggested that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.
Journal ArticleDOI
Toll-like Receptor-Induced Changes in Glycolytic Metabolism Regulate Dendritic Cell Activation
Connie M. Krawczyk,Connie M. Krawczyk,Thomas Holowka,Jie Sun,Julianna Blagih,Eyal Amiel,Ralph J. DeBerardinis,Justin R. Cross,Euihye Jung,Craig B. Thompson,Russell G. Jones,Edward J. Pearce,Edward J. Pearce +12 more
TL;DR: It is demonstrated that, in mouse DCs, TLR agonists stimulate a profound metabolic transition to aerobic glycolysis, similar to the Warburg metabolism displayed by cancer cells.
Journal ArticleDOI
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
Kurt Bachmaier,Connie M. Krawczyk,Ivona Kozieradzki,Young-Yun Kong,Takehiko Sasaki,Antonio J. Oliveira-dos-Santos,Sanjeev Mariathasan,Dennis Bouchard,Andrew Wakeham,Annick Itie,Jenny Le,Pamela S. Ohashi,Ildiko Sarosi,Hiroshi Nishina,Stan Lipkowitz,Josef M. Penninger +15 more
TL;DR: It is shown that gene-targeted mice lacking the adaptor Cbl-b develop spontaneous autoimmunity characterized by auto-antibody production, infiltration of activated T and B lymphocytes into multiple organs, and parenchymal damage.
Journal ArticleDOI
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling
Junko Irie-Sasaki,Junko Irie-Sasaki,Takehiko Sasaki,Takehiko Sasaki,Wataru Matsumoto,Anne Opavsky,Mary Cheng,G. Grant Welstead,Emily K. Griffiths,Connie M. Krawczyk,Christopher D. Richardson,Karen Aitken,Norman N. Iscove,Gary A. Koretzky,Pauline Johnson,Peter Liu,David M. Rothstein,Josef M. Penninger,Josef M. Penninger +18 more
TL;DR: Functionally, CD45 negatively regulates interleukin-3-mediated cellular proliferation, erythropoietin-dependent haematopoieisis and antiviral responses in vitro and in vivo.
Journal ArticleDOI
The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo
Julianna Blagih,François Coulombe,Emma E. Vincent,Fanny Dupuy,Gabriela Galicia-Vázquez,Ekaterina Yurchenko,Thomas C. Raissi,Gerritje J.W. van der Windt,Benoit Viollet,Erika L. Pearce,Jerry Pelletier,Ciriaco A. Piccirillo,Connie M. Krawczyk,Maziar Divangahi,Russell G. Jones +14 more
TL;DR: It is demonstrated that AMPKα1 is essential for T helper 1 and Th17 cell development and primary T cell responses to viral and bacterial infections in vivo and AMPK-dependent regulation of metabolic homeostasis as a key regulator of T cell-mediated adaptive immunity.