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Connie M. Piccone
Researcher at Boston Children's Hospital
Publications - 32
Citations - 712
Connie M. Piccone is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 9, co-authored 28 publications receiving 508 citations. Previous affiliations of Connie M. Piccone include Case Western Reserve University & Carle Foundation Hospital.
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Journal ArticleDOI
Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia - TCD with Transfusions Changing to Hydroxyurea (TWiTCH): A multicentre, open-label, phase 3, non-inferiority trial
Russell E. Ware,Barry R. Davis,William H. Schultz,R. Clark Brown,Banu Aygun,Sharada A. Sarnaik,Isaac Odame,Beng Fuh,Alex George,William Owen,Lori Luchtman-Jones,Zora R. Rogers,Lee Hilliard,Cynthia Gauger,Connie M. Piccone,Margaret T. Lee,Janet L. Kwiatkowski,Sherron M. Jackson,Scott T. Miller,Carla W. Roberts,Matthew M. Heeney,Theodosia A. Kalfa,Stephen C. Nelson,Hamayun Imran,Kerri Nottage,Ofelia A. Alvarez,Melissa Rhodes,Alexis A. Thompson,Jennifer A. Rothman,Kathleen J. Helton,Donna R. Roberts,Jamie L. Coleman,Melanie J. Bonner,Abdullah Kutlar,Niren Patel,John C. Wood,Linda B. Piller,Peng Wei,Judy Luden,Nicole A. Mortier,Susan E. Stuber,Naomi L.C. Luban,Alan R. Cohen,Sara L. Pressel,Robert J. Adams +44 more
TL;DR: High-risk children with sickle cell anaemia and abnormal TCD velocities who have received at least 1 year of transfusions, and have no MRA-defined severe vasculopathy, hydroxycarbamide treatment can substitute for chronic transfusions to maintain TCD velocity and help to prevent primary stroke.
Journal ArticleDOI
Effects of hydroxyurea treatment for patients with hemoglobin SC disease.
Lori Luchtman-Jones,Lori Luchtman-Jones,Sara L. Pressel,Lee Hilliard,R. Clark Brown,Mary G. Smith,Alexis A. Thompson,Margaret T. Lee,Jennifer A. Rothman,Zora R. Rogers,William Owen,Hamayun Imran,Courtney D. Thornburg,Janet L. Kwiatkowski,Banu Aygun,Stephen C. Nelson,Carla W. Roberts,Cynthia Gauger,Connie M. Piccone,Theodosia A. Kalfa,Ofelia A. Alvarez,Kathryn L. Hassell,Barry R. Davis,Russell E. Ware +23 more
TL;DR: Multicenter data support the safety and potentially salutary effects of hydroxyurea treatment for HbSC disease; however, a multicenter, placebo‐controlled, Phase 3 clinical trial is needed to determine if hydroxyUREa therapy has efficacy for patients with Hb SC disease.
Journal ArticleDOI
Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial
John C. Wood,Alan R. Cohen,Sara L. Pressel,Banu Aygun,Hamayun Imran,Lori Luchtman-Jones,Lori Luchtman-Jones,Alexis A. Thompson,Beng Fuh,Beng Fuh,William H. Schultz,Barry R. Davis,Russell E. Ware,Alex George,Brigitta U. Mueller,Matthew M. Heeney,Theodosia A. Kalfa,Stephen C. Nelson,R. Clark Brown,Beatrice E. Gee,Janet L. Kwiatkowski,Kim Smith Whitley,Isaac Odame,Jennifer Webb,Elizabeth Yang,Margaret T. Lee,Connie M. Piccone,Sherron M. Jackson,Sharon A. Singh,Kerri Nottage,Jane S. Hankins,Scott T. Miller,Lee Hilliard,Ofelia A. Alvarez,Melissa Rhodes,Zora R. Rogers,Sharada A. Sarnaik,William Owen,Cynthia Gauger,Carla W. Roberts,Jennifer A. Rothman +40 more
TL;DR: The baseline findings of abdominal organ iron burden are reported and extra‐hepatic iron deposition is common among children with SCA who receive chronic transfusions, and could potentiate oxidative stress caused by reperfusion injury and decellularized haemoglobin.
Journal ArticleDOI
Paper-based microchip electrophoresis for point-of-care hemoglobin testing
Muhammad Noman Hasan,Arwa Fraiwan,Ran An,Yunus Alapan,Yunus Alapan,Ryan Ung,Asya Akkus,Julia Z. Xu,Amy J. Rezac,Nicholas Kocmich,Melissa S. Creary,Tolulope Oginni,Grace Olanipekun,Fatimah Hassan-Hanga,Binta W. Jibir,Safiya Gambo,Anil Kumar Verma,Praveen K. Bharti,Suchada Riolueang,Takdanai Ngimhung,Thidarat Suksangpleng,Priyaleela Thota,Greg Werner,Rajasubramaniam Shanmugam,Aparup Das,Vip Viprakasit,Connie M. Piccone,Jane A. Little,Jane A. Little,Jane A. Little,Stephen K. Obaro,Umut A. Gurkan +31 more
TL;DR: HemeChip is a versatile, mass-producible microchip electrophoresis platform that addresses a major unmet need of decentralized hemoglobin analysis in resource-limited settings and correctly identified all subjects with hemoglobin S, C, and E variants with 100% sensitivity and displayed an overall diagnostic accuracy of 98.4% in comparison to reference standard methods.
Journal ArticleDOI
A study of the geographic distribution and associated risk factors of leg ulcers within an international cohort of sickle cell disease patients: the CASiRe group analysis.
Charles Antwi-Boasiako,Biree Andemariam,Raffaella Colombatti,Eugenia Vicky Asare,Crawford John Strunk,Connie M. Piccone,Deepa Manwani,Donna Boruchov,Fatimah Farooq,Rebekah Urbonya,Samuel Wilson,Gifty Dankwah Boatemaa,Silverio Perrotta,Laura Sainati,Angela Rivers,Sudha Rao,William T. Zempsky,Ivy Ekem,Fredericka Sey,Catherine I. Segbefia,Baba Inusa,Immacolata Tartaglione,Andrew D. Campbell,Andrew D. Campbell +23 more
TL;DR: Overall, this study identified a predominance of leg ulcers within male hemoglobin SS patients living in sub-Saharan Africa with renal dysfunction and increased hemolysis.