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Constantine J. Karvellas

Researcher at University of Alberta

Publications -  167
Citations -  5634

Constantine J. Karvellas is an academic researcher from University of Alberta. The author has contributed to research in topics: Liver transplantation & Medicine. The author has an hindex of 35, co-authored 136 publications receiving 4325 citations. Previous affiliations of Constantine J. Karvellas include University of Cambridge & King's College.

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Journal ArticleDOI

Predictors of bacteraemia and mortality in patients with acute liver failure.

Constantine J. Karvellas, +10 more
- 03 Apr 2009 - 
TL;DR: In this study, severity of hepatic encephalopathy and SIRS score >1 were predictive of bacteraemia and APACHEII was independently predictive of mortality in all ALF patients but not bacteraemic.
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Bacteremia, acute physiology and chronic health evaluation II and modified end stage liver disease are independent predictors of mortality in critically ill nontransplanted patients with acute on chronic liver failure.

Constantine J. Karvellas, +9 more
- 01 Jan 2010 - 
TL;DR: In nontransplanted patients with acute on chronic liver failure, bacteremia was associated with increased severity of illness on admission, greater requirements for organ support, and independently adversely impacted on survival.
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Effect of the clinical course of acute-on-chronic liver failure prior to liver transplantation on post-transplant survival.

Vinay Sundaram, +8 more
- 01 Mar 2020 - 
TL;DR: Improvement of ACLF-3 at listing to ACLF 0-2 at transplantation enhances post-LT survival, particularly in recipients who are older than age 60, who were removed from the mechanical ventilator, or who recovered from circulatory or brain failure.
Journal ArticleDOI

Acquired Liver Injury in the Intensive Care Unit

Thomas Lescot, +3 more
- 01 Oct 2012 - 
TL;DR: Hepatotoxicity refers to hepatic injury and dysfunction caused by a drug or another noninfectious agent, and liver injury as an elevation in serum concentrations of routinely measured hepatic enzymes is chosen.
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Patients With Acute on Chronic Liver Failure Grade 3 Have Greater 14-Day Waitlist Mortality Than Status-1a Patients

Vinay Sundaram, +7 more
- 01 Jul 2019 - 
TL;DR: Patients listed for liver transplantation as status 1a currently receive the highest priority on the waiting list, but the presence of acute on chronic liver failure with three or more organs failing (ACLF‐3) portends low survival without transplantation, which may not be reflected by the Model for End‐Stage Liver Disease‐Sodium (MELD‐Na) score.