C
Constantine J. Karvellas
Researcher at University of Alberta
Publications - 167
Citations - 5634
Constantine J. Karvellas is an academic researcher from University of Alberta. The author has contributed to research in topics: Liver transplantation & Medicine. The author has an hindex of 35, co-authored 136 publications receiving 4325 citations. Previous affiliations of Constantine J. Karvellas include University of Cambridge & King's College.
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Journal ArticleDOI
A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial.
Paul E. Wischmeyer,Michel Hasselmann,Christine Kummerlen,Rosemary Kozar,Demetrios J. Kutsogiannis,Constantine J. Karvellas,Beth Y. Besecker,David K. Evans,Jean-Charles Preiser,Leah Gramlich,Khursheed N. Jeejeebhoy,Rupinder Dhaliwal,Xuran Jiang,Andrew G. Day,Daren K. Heyland +14 more
TL;DR: Given feasibility and consistent encouraging trends in hospital mortality, QoL, and functional endpoints, a full-scale trial of SPN powered to assess these clinical outcome endpoints in high-nutritional-risk ICU patients is indicated—potentially focusing on the more poorly EN-fed surgical ICU setting.
Journal ArticleDOI
Outcomes and Complications of Intracranial Pressure Monitoring in Acute Liver Failure: A Retrospective Cohort Study*
Constantine J. Karvellas,Oren K. Fix,Holly Battenhouse,Valerie Durkalski,Corron Sanders,William M. Lee +5 more
TL;DR: The use of intracranial pressure monitor in acetaminophen acute liver failure did not confer a significant 21-day mortality benefit, whereas in nonacetaminophen Acute Liver Failure, it may be associated with worse outcomes.
Journal ArticleDOI
The Natural History of Severe Acute Liver Injury
David G. Koch,Jaime L. Speiser,Valerie Durkalski,Robert J. Fontana,Timothy Davern,Brendan M. McGuire,Richard T. Stravitz,Anne M. Larson,Iris Liou,Oren K. Fix,Michael L. Schilsky,Timothy M. McCashland,J. E. Hay,Natalie Murray,Obaid S. Shaikh,Daniel Ganger,Atif Zaman,Steven-Huy B. Han,R.T. Chung,R. S. Brown,Santiago J. Munoz,K.R. Reddy,Lorenzo Rossaro,Raj Satyanarayana,A. J. Hanje,Jody C. Olson,Ram Subramanian,Constantine J. Karvellas,Bilal Hameed,Averell H. Sherker,William M. Lee,Adrian Reuben +31 more
TL;DR: A majority of ALI cases are due to APAP, 93% of whom will improve rapidly and fully recover, while non-APAP patients have a far greater risk of poor outcome and should be targeted for early referral to a liver transplant center.
Journal ArticleDOI
Appropriate and timely antimicrobial therapy in cirrhotic patients with spontaneous bacterial peritonitis-associated septic shock: a retrospective cohort study
TL;DR: Spontaneous bacterial peritonitis (SBP)‐associated septic shock carries significant mortality in cirrhosis and should be treated with antibiotics.
Journal ArticleDOI
Acute-on-Chronic Liver Failure: Getting Ready for Prime Time?
Jasmohan S. Bajaj,Richard Moreau,Patrick S. Kamath,Hugo E. Vargas,Vicente Arroyo,K. Rajender Reddy,Gyongyi Szabo,Puneeta Tandon,Jody C. Olson,Constantine J. Karvellas,Thierry Gustot,Jennifer C. Lai,Florence Wong +12 more
TL;DR: The role of liver transplant in ACLF is evolving and needs further investigation across large consortia, and a role for early palliative care and management of frailty as approaches to alleviate disease burden and improve patient‐reported outcomes is being increasingly recognized.