C
Constantine J. Karvellas
Researcher at University of Alberta
Publications - 167
Citations - 5634
Constantine J. Karvellas is an academic researcher from University of Alberta. The author has contributed to research in topics: Liver transplantation & Medicine. The author has an hindex of 35, co-authored 136 publications receiving 4325 citations. Previous affiliations of Constantine J. Karvellas include University of Cambridge & King's College.
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Journal ArticleDOI
The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis
Mathilde Mouchiroud,Étienne Camiré,Manal Aldow,Alexandre Caron,Éric Jubinville,Laurie Turcotte,Inés Kaci,Marie Josée Beaulieu,Christian Roy,Sébastien M. Labbé,Thibault V. Varin,Yves Gélinas,Jennifer Lamothe,Jocelyn Trottier,Patricia L. Mitchell,Frédéric Guénard,William T. Festuccia,Philippe Joubert,Christopher F. Rose,Constantine J. Karvellas,Olivier Barbier,Mathieu C. Morissette,André Marette,Mathieu Laplante +23 more
TL;DR: The hepatokine TSK is identified as a blood biomarker of liver stress that could link NAFLD to the development of atherogenic dyslipidemia and atherosclerosis.
Journal ArticleDOI
Dynamic Prognostication in Critically Ill Cirrhotic Patients With Multiorgan Failure in ICUs in Europe and North America: A Multicenter Analysis
Constantine J. Karvellas,Elisabet Garcia-Lopez,Javier J.M. Fernández,Faouzi Saliba,Eric Sy,Rajiv Jalan,Marco Pavesi,Thierry Gustot,Juan J. Ronco,Vicente Arroyo +9 more
TL;DR: In high-risk ICU patients (Chronic Liver Failure-Consortium Acute on Chronic Liver Failure > 70), decisions regarding transition to palliation should be explored between patient families and the ICU providers after a short trial of therapy.
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Critical care management of the patient with cirrhosis awaiting liver transplant in the intensive care unit
TL;DR: Management of the critically ill ACLF patient awaiting transplantation is best accomplished by multidisciplinary teams with expertise in critical care and transplant medicine, and teams are well suited to address the needs of this unique patient population.
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β-Lactones as a New Class of Cysteine Proteinase Inhibitors: Inhibition of Hepatitis A Virus 3C Proteinase by N-Cbz-serine β-Lactone
TL;DR: N-Benzyloxycarbonyl-l-serine β-lactone is shown to irreversibly inactivate the 3C cysteine proteinase of hepatitis A virus (HAV) with kinact = 0.84 × 10-4 M and kinact/KΙ = 3800 M-1 min-1 at an enzyme concentration of 0.1 μM.
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Clinical and microbiological characteristics associated with mortality in spontaneous bacterial peritonitis: a multicenter cohort study.
Ana Maria Freire de Oliveira,Joana Carvalho e Branco,Rita Barosa,José A. Rodrigues,Lídia Roque Ramos,Alexandra Martins,Constantine J. Karvellas,Filipe S. Cardoso +7 more
TL;DR: In this cohort, SBP portended high early mortality and Gram-positive bacteria, bacteria resistant to quinolones, and multiresistant bacteria were identified in considerable proportions of patients.