Cor Jacobs

TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.

TL;DR: BCG induces sustained changes in the immune system associated with a nonspecific response to infections both at the level of innate trained immunity and at thelevel of heterologous Th1/Th17 responses 1 year after vaccination.

TL;DR: BCG vaccination of healthy volunteers increased proinflammatory cytokine production following ex vivo stimulation of NK cells with mycobacteria and other unrelated pathogens up until at least three months after vaccination, which suggests that NK cells may contribute to the non-specific (heterologous) beneficial effects of BCG vaccination.

TL;DR: The experiments identify the ability of monocytes to acquire adaptive characteristics after prior activation with a wide variety of ligands, and identify the two distinct and opposing functional programs induced by the specific microbial ligands engaging the monocytes.

TL;DR: During disease progression in murine Lupus erythematosus SLE, apoptotic cell clearance becomes impaired, which might amplify further disease progression.