J
Johanneke Kleinnijenhuis
Researcher at Radboud University Nijmegen
Publications - 19
Citations - 3688
Johanneke Kleinnijenhuis is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Innate immune system & Mycobacterium tuberculosis. The author has an hindex of 17, co-authored 18 publications receiving 2902 citations. Previous affiliations of Johanneke Kleinnijenhuis include Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.
Journal ArticleDOI
Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity.
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Christine Stabell Benn,Leo A. B. Joosten,Cor Jacobs,Joke van Loenhout,Ramnik J. Xavier,Peter Aaby,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +11 more
TL;DR: BCG induces sustained changes in the immune system associated with a nonspecific response to infections both at the level of innate trained immunity and at thelevel of heterologous Th1/Th17 responses 1 year after vaccination.
Journal ArticleDOI
Immunometabolic pathways in BCG-induced trained immunity
Rob J.W. Arts,Agostinho Carvalho,Claudia La Rocca,Carla Palma,Fernando Rodrigues,Ricardo Silvestre,Johanneke Kleinnijenhuis,Ekta Lachmandas,Luís G. Gonçalves,Ana Belinha,Cristina Cunha,Marije Oosting,Leo A. B. Joosten,Giuseppe Matarese,Reinout van Crevel,Mihai G. Netea +15 more
TL;DR: It is shown that BCG induction of trained immunity in monocytes is accompanied by a strong increase in glycolysis and, to a lesser extent, glutamine metabolism, both in an in-vitro model and after vaccination of mice and humans.
Journal ArticleDOI
Innate immune recognition of Mycobacterium tuberculosis.
TL;DR: Insight into pattern recognition receptors and the recognition of mycobacteria, combined with immunogenetic studies in TB patients, does not only lead to a better understanding of the pathogenesis of tuberculosis but also may contribute to the design of novel immunotherapeutic strategies.
Journal ArticleDOI
BCG-induced trained immunity in NK cells: role for non-specific protection to infection
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Cor Jacobs,Rannnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +8 more
TL;DR: BCG vaccination of healthy volunteers increased proinflammatory cytokine production following ex vivo stimulation of NK cells with mycobacteria and other unrelated pathogens up until at least three months after vaccination, which suggests that NK cells may contribute to the non-specific (heterologous) beneficial effects of BCG vaccination.