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Christine Stabell Benn
Researcher at University of Southern Denmark
Publications - 334
Citations - 13948
Christine Stabell Benn is an academic researcher from University of Southern Denmark. The author has contributed to research in topics: Vaccination & Measles vaccine. The author has an hindex of 51, co-authored 305 publications receiving 10429 citations. Previous affiliations of Christine Stabell Benn include Odense University Hospital & Copenhagen University Hospital.
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Journal ArticleDOI
Defining trained immunity and its role in health and disease
Mihai G. Netea,Mihai G. Netea,Jorge Domínguez-Andrés,Luis B. Barreiro,Luis B. Barreiro,Triantafyllos Chavakis,Triantafyllos Chavakis,Maziar Divangahi,Maziar Divangahi,Elaine Fuchs,Leo A. B. Joosten,Jos W. M. van der Meer,Musa M. Mhlanga,Musa M. Mhlanga,Willem J. M. Mulder,Willem J. M. Mulder,Niels P. Riksen,Andreas Schlitzer,Joachim L. Schultze,Christine Stabell Benn,Joseph C. Sun,Joseph C. Sun,Ramnik J. Xavier,Ramnik J. Xavier,Eicke Latz,Eicke Latz,Eicke Latz +26 more
TL;DR: A group of leaders in the field define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
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BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity
Rob J.W. Arts,Simone J.C.F.M. Moorlag,Boris Novakovic,Yang Li,Shuang-Yin Wang,Marije Oosting,Vinod Kumar,Ramnik J. Xavier,Cisca Wijmenga,Leo A. B. Joosten,Chantal B.E.M. Reusken,Christine Stabell Benn,Christine Stabell Benn,Peter Aaby,Peter Aaby,Marion Koopmans,Hendrik G. Stunnenberg,Reinout van Crevel,Mihai G. Netea,Mihai G. Netea +19 more
TL;DR: BCG vaccination induced genome-wide epigenetic reprograming of monocytes and protected against experimental infection with an attenuated yellow fever virus vaccine strain, with a key role for IL-1β as a mediator of trained immunity responses.
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Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period?
Peter Aaby,Adam Roth,Adam Roth,Henrik Ravn,Bitiguida Mutna Napirna,Amabelia Rodrigues,Ida Maria Lisse,Lone Graff Stensballe,Birgitte Rode Diness,Karen Rokkedal Lausch,Najaaraq Lund,Sofie Biering-Sørensen,Hilton Whittle,Christine Stabell Benn,Christine Stabell Benn +14 more
TL;DR: Though early BCG did not reduce infant mortality significantly, it may have a beneficial effect in the neonatal period, which could be important for public health because BCG is often delayed in low-income countries.
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Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity.
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Christine Stabell Benn,Leo A. B. Joosten,Cor Jacobs,Joke van Loenhout,Ramnik J. Xavier,Peter Aaby,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +11 more
TL;DR: BCG induces sustained changes in the immune system associated with a nonspecific response to infections both at the level of innate trained immunity and at thelevel of heterologous Th1/Th17 responses 1 year after vaccination.
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A small jab – a big effect: nonspecific immunomodulation by vaccines
TL;DR: New research suggests that the nonspecific effects of vaccines are related to cross-reactivity of the adaptive immune system with unrelated pathogens, and to training of the innate immune system through epigenetic reprogramming.