D
Daniela C. Ifrim
Researcher at Radboud University Nijmegen
Publications - 12
Citations - 4060
Daniela C. Ifrim is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Innate immune system & Immunity. The author has an hindex of 10, co-authored 12 publications receiving 3075 citations. Previous affiliations of Daniela C. Ifrim include Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Shih-Chin Cheng,Jessica Quintin,Robert A. Cramer,Kelly M. Shepardson,Sadia Saeed,Vinod Kumar,Evangelos J. Giamarellos-Bourboulis,Joost H.A. Martens,Nagesha Appukudige Rao,Ali Aghajanirefah,Ganesh R. Manjeri,Yang Li,Daniela C. Ifrim,Rob J.W. Arts,Brian M. J. W. van der Veer,Peter M.T. Deen,Colin Logie,Luke A. J. O'Neill,Peter H.G.M. Willems,Frank L. van de Veerdonk,Jos W. M. van der Meer,Aylwin Ng,Aylwin Ng,Leo A. B. Joosten,Cisca Wijmenga,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Mihai G. Netea +28 more
TL;DR: The identification of glycolysis as a fundamental process in trained immunity further highlights a key regulatory role for metabolism in innate host defense and defines a potential therapeutic target in both infectious and inflammatory diseases.
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Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Daniela C. Ifrim,Sadia Saeed,Cor Jacobs,Joke van Loenhout,Dirk J. de Jong,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Reinout van Crevel,Mihai G. Netea +14 more
TL;DR: It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.
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Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes
Jessica Quintin,Sadia Saeed,Joost H.A. Martens,Evangelos J. Giamarellos-Bourboulis,Daniela C. Ifrim,Colin Logie,Liesbeth Jacobs,Trees Jansen,Bart Jan Kullberg,Cisca Wijmenga,Leo A. B. Joosten,Ramnik J. Xavier,Jos W. M. van der Meer,Hendrik G. Stunnenberg,Mihai G. Netea +14 more
TL;DR: The functional reprogramming of monocytes, reminiscent of similar NK cell properties, supports the concept of "trained immunity" and may be employed for the design of improved vaccination strategies.
Journal ArticleDOI
Trained Immunity or Tolerance: Opposing Functional Programs Induced in Human Monocytes after Engagement of Various Pattern Recognition Receptors
Daniela C. Ifrim,Jessica Quintin,Leo A. B. Joosten,Cor Jacobs,Trees Jansen,Liesbeth Jacobs,Neil A. R. Gow,David L. Williams,Jos W. M. van der Meer,Mihai G. Netea +9 more
TL;DR: The experiments identify the ability of monocytes to acquire adaptive characteristics after prior activation with a wide variety of ligands, and identify the two distinct and opposing functional programs induced by the specific microbial ligands engaging the monocytes.
Journal ArticleDOI
Role of Dectin-2 for Host Defense against Systemic Infection with Candida glabrata
Daniela C. Ifrim,Judith M. Bain,Delyth M. Reid,Marije Oosting,Ineke Verschueren,Neil A. R. Gow,J. Han van Krieken,Gordon D. Brown,Bart Jan Kullberg,Leo A. B. Joosten,Jos W. M. van der Meer,Frank Koentgen,Lars P. Erwig,Jessica Quintin,Mihai G. Netea +14 more
TL;DR: It is suggested that Dectin-2 is important in host defense against C. glabrata and provides new insights into the host defense mechanisms against this important fungal pathogen.