C
Cornelia Wagner
Researcher at Hoffmann-La Roche
Publications - 3
Citations - 439
Cornelia Wagner is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Hapten & Protein oxidation. The author has an hindex of 3, co-authored 3 publications receiving 235 citations.
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Journal ArticleDOI
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.
Glenn R. Masson,John E. Burke,Natalie G. Ahn,Ganesh S. Anand,Christoph H. Borchers,Sébastien Brier,George M. Bou-Assaf,John R. Engen,S. Walter Englander,Johan H. Faber,Rachel Garlish,Patrick R. Griffin,Michael L. Gross,Miklos Guttman,Yoshitomo Hamuro,Albert J. R. Heck,Damian Houde,Roxana E. Iacob,Thomas J. D. Jørgensen,Igor A. Kaltashov,Judith P. Klinman,Lars Konermann,Petr Man,Leland Mayne,Bruce D. Pascal,Dana Reichmann,Mark Skehel,Joost Snijder,Timothy S. Strutzenberg,Eric S. Underbakke,Cornelia Wagner,Thomas E. Wales,Benjamin T. Walters,David D. Weis,Derek J. Wilson,Patrick L. Wintrode,Zhongqi Zhang,Jie Zheng,David C. Schriemer,Kasper D. Rand +39 more
TL;DR: Recommendations arising from community discussions emerging out of the first International Conference on Hydrogen-Exchange Mass Spectrometry (IC-HDX; 2017) are provided, meant to represent both a consensus viewpoint and an opportunity to stimulate further additions and refinements as the field advances.
Journal ArticleDOI
Hapten-directed spontaneous disulfide shuffling: a universal technology for site-directed covalent coupling of payloads to antibodies
Stefan Dengl,Eike Hoffmann,Michael Grote,Cornelia Wagner,Olaf Mundigl,Guy Georges,Irmgard Thorey,Kay-Gunnar Stubenrauch,Alexander Bujotzek,Hans-Peter Josel,Sebastian Dziadek,Joerg Benz,Ulrich Brinkmann +12 more
TL;DR: The coupling technology is applicable to many haptens and hapten binding antibodies and can be applied to modulate the pharma‐cokinetics of small compounds or peptides and is suitable to link payloads in a reduction‐releasable manner to tumor‐ or tissue‐targeting delivery vehicles.
Journal ArticleDOI
Hydrogen/deuterium exchange mass spectrometry with improved electrochemical reduction enables comprehensive epitope mapping of a therapeutic antibody to the cysteine-knot containing vascular endothelial growth factor.
Gerard Comamala,Cornelia Wagner,Pablo Sanz de la Torre,Rasmus U. Jakobsen,Maximiliane Hilger,Hendrik-Jan Brouwer,Kasper D. Rand +6 more
TL;DR: Overall, the findings show how ER and HDX-MS can be combined to enable analysis of the conformation and interactions of challenging disulfide-rich proteins.