J
Johan H. Faber
Researcher at Novo Nordisk
Publications - 13
Citations - 935
Johan H. Faber is an academic researcher from Novo Nordisk. The author has contributed to research in topics: Hydrogen–deuterium exchange & Ligand (biochemistry). The author has an hindex of 12, co-authored 13 publications receiving 698 citations. Previous affiliations of Johan H. Faber include Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.
Glenn R. Masson,John E. Burke,Natalie G. Ahn,Ganesh S. Anand,Christoph H. Borchers,Sébastien Brier,George M. Bou-Assaf,John R. Engen,S. Walter Englander,Johan H. Faber,Rachel Garlish,Patrick R. Griffin,Michael L. Gross,Miklos Guttman,Yoshitomo Hamuro,Albert J. R. Heck,Damian Houde,Roxana E. Iacob,Thomas J. D. Jørgensen,Igor A. Kaltashov,Judith P. Klinman,Lars Konermann,Petr Man,Leland Mayne,Bruce D. Pascal,Dana Reichmann,Mark Skehel,Joost Snijder,Timothy S. Strutzenberg,Eric S. Underbakke,Cornelia Wagner,Thomas E. Wales,Benjamin T. Walters,David D. Weis,Derek J. Wilson,Patrick L. Wintrode,Zhongqi Zhang,Jie Zheng,David C. Schriemer,Kasper D. Rand +39 more
TL;DR: Recommendations arising from community discussions emerging out of the first International Conference on Hydrogen-Exchange Mass Spectrometry (IC-HDX; 2017) are provided, meant to represent both a consensus viewpoint and an opportunity to stimulate further additions and refinements as the field advances.
Journal ArticleDOI
Human metabolic profiles are stably controlled by genetic and environmental variation
George Nicholson,Mattias Rantalainen,Anthony D. Maher,Jia V. Li,Daniel Malmodin,Kourosh R. Ahmadi,Johan H. Faber,Ingileif B. Hallgrímsdóttir,Amy Barrett,Henrik Toft,Maria Krestyaninova,Juris Viksna,Sudeshna Guha Neogi,Marc-Emmanuel Dumas,Ugis Sarkans,Bernard W. Silverman,Bernard W. Silverman,Peter Donnelly,Peter Donnelly,Jeremy K. Nicholson,Jeremy K. Nicholson,Maxine Allen,Krina T. Zondervan,John C. Lindon,Tim D. Spector,Mark I. McCarthy,Elaine Holmes,Elaine Holmes,Dorrit Baunsgaard,Christopher Holmes +29 more
TL;DR: A power‐calculation method is provided which reveals that sample sizes of a few thousand should offer sufficient statistical precision to detect 1H NMR‐based biomarkers quantifying predisposition to disease.
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A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.
George Nicholson,Mattias Rantalainen,Jia V. Li,Anthony D. Maher,Daniel Malmodin,Kourosh R. Ahmadi,Johan H. Faber,Amy Barrett,Josine L. Min,N. William Rayner,N. William Rayner,Henrik Toft,Maria Krestyaninova,Juris Viksna,Sudeshna Guha Neogi,Marc-Emmanuel Dumas,Ugis Sarkans,Peter Donnelly,Peter Donnelly,Thomas Illig,Jerzy Adamski,Karsten Suhre,Maxine Allen,Krina T. Zondervan,Tim D. Spector,Jeremy K. Nicholson,John C. Lindon,Dorrit Baunsgaard,Elaine Holmes,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Christopher Holmes +32 more
TL;DR: A previously uncharacterized yet substantial familial component of variation in metabolite levels in addition to the heritability contribution from the corresponding mQTL effects is discovered.
Journal ArticleDOI
Optimization of human plasma 1H NMR spectroscopic data processing for high-throughput metabolic phenotyping studies and detection of insulin resistance related to type 2 diabetes.
Anthony D. Maher,Derek Crockford,Henrik Toft,Daniel Malmodin,Johan H. Faber,Mark I. McCarthy,Amy Barrett,Maxine Allen,Mark Walker,Elaine Holmes,John C. Lindon,Jeremy K. Nicholson +11 more
TL;DR: Two different types of mathematical transformation are applied to attenuate broad spectral features from macromolecules and enhance the signals of small molecules to identify potential biomarkers as spin-echo (1)H NMR spectra in which broad lines are suppressed via T2 relaxation editing.
Journal ArticleDOI
Factor VIII C1-domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake
Esther Bloem,Maartje van den Biggelaar,Aleksandra Wroblewska,Jan Voorberg,Johan H. Faber,Marianne Kjalke,Henning R. Stennicke,Koen Mertens,Alexander B. Meijer +8 more
TL;DR: Hydrogen-deuterium exchange mass spectrometry suggests that the C1 domain spikes 2092–2093 and 2158–2159 together modulate FVIII membrane assembly by a subtle, PS-dependent mechanism.