C
Costantino Iadecola
Researcher at Cornell University
Publications - 468
Citations - 59815
Costantino Iadecola is an academic researcher from Cornell University. The author has contributed to research in topics: Stroke & Ischemia. The author has an hindex of 107, co-authored 435 publications receiving 51044 citations. Previous affiliations of Costantino Iadecola include University of Chicago & University of Minnesota.
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Journal ArticleDOI
Sex differences in angiotensin signaling in bulbospinal neurons in the rat rostral ventrolateral medulla
Gang Wang,Teresa A. Milner,Robert C. Speth,Andrea C. Gore,Di Wu,Costantino Iadecola,Joseph P. Pierce +6 more
TL;DR: Observations suggest that an increase in AT(1) receptors in female RVLM neurons is counterbalanced by a reduction in p47 levels, such that ANG II-induced ROS production does not differ between females and males.
Journal ArticleDOI
A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage
Santosh B. Murthy,Sung Min Cho,Ajay Gupta,Ashkan Shoamanesh,Babak B. Navi,Radhika Avadhani,Joshua J. Gruber,Yunke Li,Tatiana Greige,Vasileios-Arsenios Lioutas,Casey Norton,Cenai Zhang,Pitchaiah Mandava,Costantino Iadecola,Guido J. Falcone,Kevin N. Sheth,Alessandro Biffi,Jonathan Rosand,Adnan I Qureshi,Joshua N. Goldstein,Chelsea S. Kidwell,Issam A. Awad,Magdy Selim,Daniel F. Hanley,Daniel Woo,Hooman Kamel,Wendy C. Ziai +26 more
TL;DR: In a large, heterogeneous cohort of prospectively identified patients with ICH, results were consistent with the hypothesis that DWI lesions represent acute sequelae of chronic cerebral small vessel disease, particularly hypertensive vasculopathy.
Journal ArticleDOI
Atherosclerosis and neurodegeneration: unexpected conspirators in Alzheimer's dementia.
TL;DR: Examining consecutive autopsy cases in which a diagnosis of AD was made according to well established neuropathological criteria found that the incidence of vascular narrowing due to atherosclerosis of the circle of Willis is greater in AD than in nondemented controls, and the number of stenoses greater than in controls.
Journal ArticleDOI
Lipopolysaccharide Induces Early Tolerance to Excitotoxicity via Nitric Oxide and cGMP
TL;DR: The findings suggest that LPS can trigger signaling between endothelial cells and neurons, leading to NO production and cGMP-dependent neuroprotection, at variance with delayed tolerance, which depends on inducible NO synthase and peroxynitrite.
Journal Article
The link between angiotensin II-mediated anxiety and mood disorders with NADPH oxidase-induced oxidative stress.
Feng Liu,Jennifer Havens,Qi Yu,Gang Wang,Robin L. Davisson,Virginia M. Pickel,Costantino Iadecola +6 more
TL;DR: An overview of the link between the renin-angiotensin system and anxiety or mood disorders is provided, and recent advances in the understanding of AngII-linked, NADPH oxidase-derived oxidative stress in the central nervous system are focused on.