Costantino Iadecola

TL;DR: It is demonstrated that PHB promotes OMA1 turnover, effectively decreasing the pool of OPA1, and it is shown that Oma1 binds to cardiolipin (CL), a major mitochondrial phospholipid, which suggests PHB-mediated CL stabilization regulates stress responses and cell death through OMA 1 turnover and cyt c release.

TL;DR: Testing the hypothesis that changes in ovarian hormones with age promote susceptibility to AngII hypertension, and influence NMDA receptor NR1 subunit trafficking in ERβ‐containing PVN neurons suggests that, in young female mice, NR1 density is decreased in ER β‐PVN dendrites thus reducingNMDA receptor activity and preventing hypertension.

TL;DR: In patients with largely normal liver chemistries, 2 liver fibrosis indices were associated with admission hematoma volume, hematomas expansion, and mortality after intracerebral hemorrhage, and Indices were not associated with the composite of major disability or death.

TL;DR: A prioritized set of recommendations for NHLBI to establish a focused and comprehensive set of research activities in cerebrovascular biology and disease was developed.

TL;DR: Case series without control groups suggest that Covid-19 may cause ischemic stroke, but whether Covd-19 is associated with a higher risk of isChemic stroke than would be expected from a viral respiratory infection is uncertain.