Costantino Iadecola

TL;DR: Accumulating evidence suggests that whole populations experiencing improved education, and lower vascular risk factor profiles and vascular disease, including stroke, have better cognitive function and lower dementia rates and the World Stroke Organization has issued a proclamation calling for the joint prevention of stroke and dementia.

TL;DR: This paper found that microglial CD36 is a key determinant of post-ischemic IL-1β production by regulating caspase-1 activity, whereas endothelial CD36 was required for the full expression of the endothelial activation induced by IL 1β.

TL;DR: This model of neuroprotection may facilitate clinical efforts to increase the efficacy of bone marrow mononuclear cell treatments in acute neurological diseases such as cerebral ischemia and provide the rationale for cell therapies based on the delivery of autologous or allogeneic protective monocytes into patients with ischemic stroke.

TL;DR: The emphasis was on cerebrovascular dysregulation and small vessel white matter disease, drawing from animal models, human pathology, neuroimaging, epidemiology, and the recent clinical trial in CADASIL, as summarized below.

TL;DR: A heightened risk of arterial isChemic events driven by an increased risk of ischemic stroke, in the 4 weeks after nontraumatic SDH is found, due to interruption of antithrombotic therapy after SDH diagnosis.