B
Bronwyn MacInnis
Researcher at Broad Institute
Publications - 90
Citations - 10913
Bronwyn MacInnis is an academic researcher from Broad Institute. The author has contributed to research in topics: Population & Plasmodium falciparum. The author has an hindex of 40, co-authored 84 publications receiving 8500 citations. Previous affiliations of Bronwyn MacInnis include Harvard University & Wellcome Trust Sanger Institute.
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Journal ArticleDOI
Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
Elizabeth A. Ashley,Mehul Dhorda,Rick M. Fairhurst,Chanaki Amaratunga,Pharath Lim,Seila Suon,Sokunthea Sreng,Jennifer M. Anderson,Mao S,Sam B,Chantha Sopha,Char Meng Chuor,Chea Nguon,Siv Sovannaroth,Sasithon Pukrittayakamee,Podjanee Jittamala,Kesinee Chotivanich,K Chutasmit,C Suchatsoonthorn,R Runcharoen,Tran Tinh Hien,Nguyen Thuy-Nhien,Thanh Nv,Nguyen Hoan Phu,Ye Htut,Han Kt,Kyin Hla Aye,Olugbenga A. Mokuolu,Rasaq Olaosebikan,Olaleke Oluwasegun Folaranmi,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Paul N. Newton,M A Onyamboko,Caterina I. Fanello,Antoinette Tshefu,Neelima Mishra,Neena Valecha,Aung Pyae Phyo,François Nosten,Yi P,Rupam Tripura,Steffen Borrmann,Mahfudh Bashraheil,Judy Peshu,M A Faiz,Aniruddha Ghose,M A Hossain,Rasheda Samad,M. R. Rahman,Manal Hasan,Ashraful Islam,Olivo Miotto,Roberto Amato,Bronwyn MacInnis,Jim Stalker,Dominic P. Kwiatkowski,Zbynek Bozdech,Atthanee Jeeyapant,Phaik Yeong Cheah,Tharisara Sakulthaew,Jeremy Chalk,Benjamas Intharabut,Kamolrat Silamut,Lee Sj,Benchawan Vihokhern,Chanon Kunasol,Mallika Imwong,Joel Tarning,Taylor Wj,Shunmay Yeung,Charles J. Woodrow,Jennifer A. Flegg,Debashish Das,Jennifer L. Smith,Meera Venkatesan,Christopher V. Plowe,Kasia Stepniewska,Philippe J Guerin,Arjen M. Dondorp,Nicholas P. J. Day,Nicholas J. White +82 more
TL;DR: Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing, and the incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission.
Journal ArticleDOI
Field-deployable viral diagnostics using CRISPR-Cas13
Cameron Myhrvold,Cameron Myhrvold,Catherine A. Freije,Catherine A. Freije,Jonathan S. Gootenberg,Omar O. Abudayyeh,Hayden C. Metsky,Ann Durbin,Ann Durbin,Max J. Kellner,Amanda L Tan,Lauren M. Paul,Leda Parham,Kimberly García,Kayla G. Barnes,Kayla G. Barnes,Bridget Chak,Bridget Chak,Adriano Mondini,Maurício Lacerda Nogueira,Sharon Isern,Scott F. Michael,Ivette Lorenzana,Nathan L. Yozwiak,Nathan L. Yozwiak,Bronwyn MacInnis,Bronwyn MacInnis,Irene Bosch,Irene Bosch,Lee Gehrke,Lee Gehrke,Feng Zhang,Pardis C. Sabeti +32 more
TL;DR: The Cas13-based SHERLOCK platform can detect Zika virus and dengue virus in patient samples at concentrations as low as 1 copy per microliter and can distinguish the four DENV serotypes, as well as region-specific strains of ZIKV from the 2015–2016 pandemic.
Journal ArticleDOI
Optimizing Illumina next-generation sequencing library preparation for extremely AT-biased genomes.
Samuel O. Oyola,Thomas D. Otto,Yong-ping Gu,Gareth Maslen,Magnus Manske,Susana Campino,Daniel J. Turner,Bronwyn MacInnis,Dominic P. Kwiatkowski,Harold Swerdlow,Michael A. Quail +10 more
TL;DR: A robust and optimized Next-Generation Sequencing library amplification method suitable for extremely AT-rich genomes and will greatly benefit sequencing clinical samples that often require amplification due to low mass of DNA starting material is developed.
Journal ArticleDOI
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
Olivo Miotto,Roberto Amato,Elizabeth A. Ashley,Bronwyn MacInnis,Jacob Almagro-Garcia,Chanaki Amaratunga,Pharath Lim,Daniel Mead,Samuel O. Oyola,Mehul Dhorda,Mallika Imwong,Charles J. Woodrow,Magnus Manske,Jim Stalker,Eleanor Drury,Susana Campino,Lucas Amenga-Etego,Thanh T-Nn.,Hien Tinh Tran,Pascal Ringwald,Delia Bethell,François Nosten,Aung Pyae Phyo,S Pukrittayakamee,Kesinee Chotivanich,Char Meng Chuor,Chea Nguon,Seila Suon,Sokunthea Sreng,Paul N. Newton,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Ye Htut,K T Han,Myat Phone Kyaw,MA Faiz,Caterina I. Fanello,M A Onyamboko,Olugbenga A. Mokuolu,Christopher G Jacob,Shannon Takala-Harrison,Christopher V. Plowe,Nicholas P. J. Day,Arjen M. Dondorp,Spencer Cca.,Gil McVean,Rick M. Fairhurst,Nicholas J. White,Dominic P. Kwiatkowski +49 more
TL;DR: Analysis of the fine structure of the parasite population showed that the fd, arps10, mdr2 and crt polymorphisms are markers of a genetic background on which kelch13 mutations are particularly likely to arise and that they correlate with the contemporary geographical boundaries and population frequencies of artemisinin resistance.
Journal ArticleDOI
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
Magnus Manske,Magnus Manske,Olivo Miotto,Olivo Miotto,Susana Campino,Susana Campino,Sarah Auburn,Sarah Auburn,Sarah Auburn,Jacob Almagro-Garcia,Jacob Almagro-Garcia,Jacob Almagro-Garcia,Gareth Maslen,Gareth Maslen,John O'Brien,John O'Brien,Abdoulaye A. Djimde,Ogobara K. Doumbo,Issaka Zongo,Jean-Bosco Ouédraogo,Pascal Michon,Ivo Mueller,Peter Siba,Alexis Nzila,Steffen Borrmann,Steven M. Kiara,Kevin Marsh,Hongying Jiang,Xin-zhuan Su,Chanaki Amaratunga,Rick M. Fairhurst,Duong Socheat,François Nosten,François Nosten,Mallika Imwong,Nicholas J. White,Nicholas J. White,Mandy Sanders,Elisa Anastasi,Dan Alcock,Eleanor Drury,Samuel O. Oyola,Michael A. Quail,Daniel J. Turner,Valentin Ruano-Rubio,Valentin Ruano-Rubio,Valentin Ruano-Rubio,Dushyanth Jyothi,Dushyanth Jyothi,Lucas Amenga-Etego,Lucas Amenga-Etego,Christina Hubbart,Anna E. Jeffreys,Kate Rowlands,Colin J. Sutherland,Cally Roper,Valentina D. Mangano,David Modiano,John C. Tan,Michael T. Ferdig,Alfred Amambua-Ngwa,David J. Conway,Shannon Takala-Harrison,Christopher V. Plowe,Julian C. Rayner,Kirk A. Rockett,Kirk A. Rockett,Kirk A. Rockett,Taane G. Clark,Taane G. Clark,Taane G. Clark,Chris I. Newbold,Chris I. Newbold,Matthew Berriman,Bronwyn MacInnis,Bronwyn MacInnis,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +78 more
TL;DR: Methods for the large-scale analysis of genetic variation in Plasmodium falciparum by deep sequencing of parasite DNA obtained from the blood of patients with malaria, either directly or after short-term culture are described.