Cynthia Alexander Rascon

TL;DR: Deep RNA sequencing of the blastema over a time course in the axolotl found a prominent burst in oncogene expression during the first day and blastemal/limb bud genes peaking at 7 to 14 days, and genes involved in angiogenesis, wound healing, defense/immunity, and bone development are enriched during blastema formation and development.

TL;DR: A set of genes that are expressed specifically during regeneration and are therefore, likely candidates for the regulation of blastema formation are identified.

TL;DR: It is reported that different vertebrate Pou 2 and Oct4 homologues can induce pluripotency in mouse and human fibroblasts and that the inability of zebrafish Pou2 to establish pluripOTency is not representative of all POU2 genes, as medaka Pou3 and axolotl Pou1 are able to reprogram somatic cells into pluripotent cells.

TL;DR: Interestingly, the recently identified Pou domain gene from Hydractinia18 appears to have the features of an Oct4/Pou2 precursor gene, as shown in Fig. 1.