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Hamisha Ardalani
Researcher at Morgridge Institute for Research
Publications - 7
Citations - 318
Hamisha Ardalani is an academic researcher from Morgridge Institute for Research. The author has contributed to research in topics: Induced pluripotent stem cell & Tissue engineering. The author has an hindex of 6, co-authored 7 publications receiving 266 citations. Previous affiliations of Hamisha Ardalani include Wisconsin Alumni Research Foundation & University of Wisconsin-Madison.
Papers
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Journal ArticleDOI
Comparative RNA-seq Analysis in the Unsequenced Axolotl: The Oncogene Burst Highlights Early Gene Expression in the Blastema
Ron Stewart,Cynthia Alexander Rascon,Shulan Tian,Jeff Nie,Christopher Barry,Li-Fang Chu,Hamisha Ardalani,Ryan J. Wagner,Mitchell D. Probasco,Jennifer M. Bolin,Ning Leng,Srikumar Sengupta,Michael Volkmer,Bianca Habermann,Elly M. Tanaka,James A. Thomson,James A. Thomson,James A. Thomson,Colin N. Dewey +18 more
TL;DR: Deep RNA sequencing of the blastema over a time course in the axolotl found a prominent burst in oncogene expression during the first day and blastemal/limb bud genes peaking at 7 to 14 days, and genes involved in angiogenesis, wound healing, defense/immunity, and bone development are enriched during blastema formation and development.
Journal ArticleDOI
Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels
Matthew R. Zanotelli,Hamisha Ardalani,Jue Zhang,Zhonggang Hou,Eric H. Nguyen,Scott Swanson,Bao Kim Nguyen,Jennifer M. Bolin,Angela L. Elwell,Lauren L. Bischel,Angela W. Xie,Ron Stewart,David J. Beebe,James A. Thomson,Michael P. Schwartz,William L. Murphy +15 more
TL;DR: It is demonstrated that iPSC-ECs formed vascular networks through mechanisms that were consistent with in vivo vasculogenesis and angiogenesis when cultured in PEG hydrogels, offering a defined platform for investigating vascular morphogenesis in vitro using both standard and microfluidic formats.
Journal ArticleDOI
3-D culture and endothelial cells improve maturity of human pluripotent stem cell-derived hepatocytes.
Hamisha Ardalani,Srikumar Sengupta,Victoria Harms,Vernella Vickerman,James A. Thomson,William L. Murphy +5 more
TL;DR: It is shown that 3D culture of iPS-derived hepatocytes and their co-culture with human sinusoidal endothelial cells (sECs) to improve their maturity is shown, suggesting that the iHEP/EC aggregates described here may have the potential to be used for many applications, including as an in vitro model to study liver diseases associated with sinusoid endothelial Cells.
Journal ArticleDOI
A Genome-wide Analysis of Human Pluripotent Stem Cell-Derived Endothelial Cells in 2D or 3D Culture.
Jue Zhang,Michael P. Schwartz,Zhonggang Hou,Yongsheng Bai,Hamisha Ardalani,Scott Swanson,John Steill,Victor Ruotti,Angela L. Elwell,Bao Kim Nguyen,Jennifer M. Bolin,Ron Stewart,James A. Thomson,James A. Thomson,James A. Thomson,William L. Murphy +15 more
TL;DR: RNA sequencing demonstrated that gene expression profiles were similar for endothelial cells and pericytes cocultured in polyethylene glycol (PEG) hydrogels or Matrigel, while monoculture comparisons identified distinct vascular signatures for each cell type.
Book ChapterDOI
Structure, Function, and Development of Blood Vessels: Lessons for Tissue Engineering
TL;DR: There is a considerable clinical need for alternatives to the autologous vein and artery tissues used for vascular reconstructive surgeries such as lower limb bypass, arteriovenous shunts, and repairs of congenital defects to the pulmonary outflow tract.