J
James P. Carney
Researcher at University of Maryland, Baltimore
Publications - 25
Citations - 4729
James P. Carney is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: DNA repair & Rad50. The author has an hindex of 19, co-authored 25 publications receiving 4571 citations. Previous affiliations of James P. Carney include University of California, San Francisco & Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.
James P. Carney,James P. Carney,Richard S. Maser,Heidi A. Olivares,Elizabeth M. Davis,Michelle M. Le Beau,John R. Yates,Lara G. Hays,William F. Morgan,William F. Morgan,John H.J. Petrini +10 more
TL;DR: The isolated p95 gene encoding p95, a member of the hMre11/hRad50 double-strand break repair complex, reveals a direct molecular link between DSB repair and cell cycle checkpoint functions in NBS.
Journal ArticleDOI
Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily.
Karl-Peter Hopfner,Annette Karcher,David S. Shin,Lisa Craig,L. Matthew Arthur,James P. Carney,John A. Tainer +6 more
TL;DR: Unified molecular mechanisms for ATP-driven cooperativity and allosteric control of ABC-ATPases in DSBR, membrane transport, and chromosome condensation by SMC proteins are suggested.
Journal ArticleDOI
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair
Karl-Peter Hopfner,Lisa Craig,Gabriel Moncalián,Robert A. Zinkel,Takehiko Usui,Barbara A.L. Owen,Annette Karcher,Brendan Henderson,Jean Luc Bodmer,Cynthia T. McMurray,James P. Carney,John H.J. Petrini,John A. Tainer +12 more
TL;DR: Data support an architectural role for the Rad50 coiled coils in forming metal-mediated bridging complexes between two DNA-binding heads that have appropriate lengths and conformational properties to link sister chromatids in homologous recombination and DNA ends in non-homologous end-joining.
Journal ArticleDOI
Structural Biochemistry and Interaction Architecture of the DNA Double-Strand Break Repair Mre11 Nuclease and Rad50-ATPase
Karl-Peter Hopfner,Annette Karcher,Lisa Craig,Tammy T. Woo,James P. Carney,John A. Tainer,John A. Tainer +6 more
TL;DR: To clarify functions of the Mre11/Rad50 (MR) complex in DNA double-strand break repair, crystal structures are reported, revealing a protein phosphatase-like, dimanganese binding domain capped by a unique domain controlling active site access.
Journal ArticleDOI
Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
R. Scott Williams,Gabriel Moncalián,Jessica S. Williams,Yoshiki Yamada,Oliver Limbo,David S. Shin,Lynda M. Groocock,Dana Cahill,Chiharu Hitomi,Grant Guenther,Davide Moiani,James P. Carney,Paul Russell,John A. Tainer,John A. Tainer +14 more
TL;DR: Results show how Mre11 dimerization and nuclease activities initiate repair of DSBs and collapsed replication forks, as well as provide a molecular foundation for understanding cancer-causing Mre 11 mutations in ataxia telangiectasia-like disorder (ATLD).