D
D. Averill
Researcher at Institute of Cancer Research
Publications - 8
Citations - 2791
D. Averill is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 8, co-authored 8 publications receiving 2704 citations.
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Journal ArticleDOI
Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
Richard Wooster,Susan L. Neuhausen,Jonathan Mangion,Yvette Quirk,D Ford,N. Collins,K. Nguyen,Sheila Seal,T.D. Tran,D. Averill,P Fields,Gill Marshall,Steven A. Narod,Gilbert M. Lenoir,Henry T. Lynch,Jean Feunteun,Peter Devilee,Cees J. Cornelisse,Fred H. Menko,Peter A. Daly,Wilma Ormiston,Ross McManus,Carole Pye,Cathryn M. Lewis,Lisa A. Cannon-Albright,Julian Peto,Bruce A.J. Ponder,Mark H. Skolnick,Douglas F. Easton,David E. Goldgar,Michael R. Stratton +30 more
TL;DR: This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13, which preliminary evidence suggests suggests confers a high risk of breast cancer but does not confer a substantially elevated risk of ovarian cancer.
Journal ArticleDOI
Cancer risks in two large breast cancer families linked to BRCA2 on chromosome 13q12-13.
Doug Easton,Linda Steele,P Fields,W. Ormiston,D. Averill,P A Daly,Ross McManus,Susan L. Neuhausen,D Ford,Richard Wooster,Lisa A. Cannon-Albright,Michael R. Stratton,David E. Goldgar +12 more
TL;DR: The results indicate that the lifetime breast cancer risk in BRCA2 carriers, for at least a subset of mutations, is comparable to that for BRCa1.
Journal ArticleDOI
A germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifenstein syndrome.
Richard Wooster,Jonathan Mangion,Rosalind A. Eeles,Simon A. Smith,Mitchell Dowsett,D. Averill,Peter Barrett-Lee,Douglas F. Easton,Bruce A.J. Ponder,Michael R. Stratton +9 more
TL;DR: A family in which two brothers who both developed breast cancer had clinical and endocrinological evidence of androgen resistance is reported, the first report of a germline mutation in a member of the steroid/thyroid hormone receptor superfamily associated with the development of cancer.
Journal Article
Constitutional mutation in exon 8 of the p53 gene in a patient with multiple primary tumours: molecular and immunohistochemical findings
Rosalind A. Eeles,William H. Warren,G. Knee,Jiri Bartek,D. Averill,Michael R. Stratton,Peter Blake,Diana Tait,David P. Lane,Doug Easton +9 more
TL;DR: It is demonstrated that formalin-preserved material from these tumours contains the same C-->T mutation at codon 273, indicating that this mutation has probably been transmitted through the germline.
Journal Article
No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families.
William H. Warren,Rosalind A. Eeles,Bruce Ponder,Doug Easton,D. Averill,M. A. Ponder,Anderson K,Evans Am,Robert DeMars,Love R +9 more
TL;DR: The results of this study indicate that familial breast cancer does not usually result from germline point mutations in the p53 gene.