J
Jean Feunteun
Researcher at Institut Gustave Roussy
Publications - 117
Citations - 11540
Jean Feunteun is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Cancer & Germline mutation. The author has an hindex of 44, co-authored 115 publications receiving 11174 citations. Previous affiliations of Jean Feunteun include Centre national de la recherche scientifique & Harvard University.
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Journal ArticleDOI
Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
Richard Wooster,Susan L. Neuhausen,Jonathan Mangion,Yvette Quirk,D Ford,N. Collins,K. Nguyen,Sheila Seal,T.D. Tran,D. Averill,P Fields,Gill Marshall,Steven A. Narod,Gilbert M. Lenoir,Henry T. Lynch,Jean Feunteun,Peter Devilee,Cees J. Cornelisse,Fred H. Menko,Peter A. Daly,Wilma Ormiston,Ross McManus,Carole Pye,Cathryn M. Lewis,Lisa A. Cannon-Albright,Julian Peto,Bruce A.J. Ponder,Mark H. Skolnick,Douglas F. Easton,David E. Goldgar,Michael R. Stratton +30 more
TL;DR: This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13, which preliminary evidence suggests suggests confers a high risk of breast cancer but does not confer a substantially elevated risk of ovarian cancer.
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Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
Ralph Scully,Junjie Chen,Annemieke W. Plug,Yonghong Xiao,David R. Weaver,Jean Feunteun,Terry Ashley,David M. Livingston +7 more
TL;DR: Findings suggest a functional interaction between BRCA1 and Rad51 in the meiotic and mitotic cell cycles, which, in turn, suggests a role for BRC a1 in the control of recombination and of genome integrity.
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Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage
Ralph Scully,Junjie Chen,Robert L. Ochs,Kathleen S. Keegan,Merl F. Hoekstra,Jean Feunteun,David M. Livingston +6 more
TL;DR: The data imply that the BRCA1 S phase foci are dynamic physiological elements, responsive to DNA damage, and that B RCA1-containing multiprotein complexes participate in a replication checkpoint response.
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Familial breast-ovarian cancer locus on chromosome 17q12-q23
Steven A. Narod,Jean Feunteun,Henry T. Lynch,Patrice Watson,T. Conway,Jane F. Lynch,Gilbert M. Lenoir +6 more
TL;DR: Findings suggest that the chromosomal region 17q12-q23, previously shown to contain a gene for early-onset breast cancer, is also associated with a proportion of hereditary ovarian cancers.
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PML induces a novel caspase-independent death process
TL;DR: It is shown that PML overexpression induces rapid cell death, independent of de novo transcription and cell cycling, and this findings reveal a novel cell death pathway that neither requires nor induces caspase-3 activation, and suggest that NBs participate in the control of cell survival.