D. Michele Basso

TL;DR: The differing behavioral response to SCI suggests inherent genetic factors significantly impact locomotor recovery and must be considered in studies with inbred or genetically engineered mouse strains.

TL;DR: It is suggested that rhythmic, weight-bearing exercise may be an effective intervention to counter SCI-induced allodynia, and greater recovery from allodynian correlated significantly with the degree of normalization of central and peripheral BDNF levels.

TL;DR: It is found that SCI elicits below-level allodynia of similar magnitude to at-level pain caused by a peripheral nerve injury, and the presence of robust microglial activation in L5 cord predicted allodyia in 86% of rats, suggesting that remote microglia activation is pivotal in the development and maintenance of below- level allodynian after SCI.

TL;DR: A way forward for when and where biomarkers can be included in clinical trials is proposed to advance the efficacy of the practice of, and research into, rehabilitation and recovery after stroke.

TL;DR: The data suggest that endogenous MBP-reactive lymphocytes, activated by traumatic SCI, can contribute to tissue injury and impair functional recovery and any neuroprotection afforded by myelin- reactive T-cells is likely to be an indirect effect mediated by other non-CNS-reacting lymphocytes.