Biomarkers of stroke recovery: consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable
Lara A. Boyd,Kathryn S Hayward,Nick S. Ward,Cathy M. Stinear,Charlotte Rosso,Rebecca J Fisher,Alexandre R. Carter,Alexander P. Leff,David A. Copland,Leeanne M. Carey,Leonardo G. Cohen,D. Michele Basso,Jane Maguire,Steven C. Cramer +13 more
TLDR
A way forward for when and where biomarkers can be included in clinical trials is proposed to advance the efficacy of the practice of, and research into, rehabilitation and recovery after stroke.Abstract:
The most difficult clinical questions in stroke rehabilitation are “What is this patient’s potential for recovery?” and “What is the best rehabilitation strategy for this person, given her/his clinical profile?” Without answers to these questions, clinicians struggle to make decisions regarding the content and focus of therapy, and researchers design studies that inadvertently mix participants who have a high likelihood of responding with those who do not. Developing and implementing biomarkers that distinguish patient subgroups will help address these issues and unravel the factors important to the recovery process. The goal of the present paper is to provide a consensus statement regarding the current state of the evidence for stroke recovery biomarkers. Biomarkers of motor, somatosensory, cognitive and language domains across the recovery timeline post-stroke are considered; with focus on brain structure and function, and exclusion of blood markers and genetics. We provide evidence for biomarkers that are considered ready to be included in clinical trials, as well as others that are promising but not ready and so represent a developmental priority. We conclude with an example that illustrates the utility of biomarkers in recovery and rehabilitation research, demonstrating how the inclusion of a biomarker may enhance future clinical trials. In this way, we propose a way forward for when and where we can include biomarkers to advance the efficacy of the practice of, and research into, rehabilitation and recovery after stroke.read more
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Standardized measurement of sensorimotor recovery in stroke trials: consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable
Gert Kwakkel,Natasha A. Lannin,Karen Borschmann,Coralie English,Myzoon Ali,Myzoon Ali,Leonid Churilov,Gustavo Saposnik,Carolee J. Winstein,Erwin E. H. van Wegen,Steven L. Wolf,John W. Krakauer,Julie Bernhardt +12 more
TL;DR: The results of a consensus meeting about measurement standards and patient characteristics that should be collected in all future stroke recovery trials are presented and a strong case is made for addition of kinematic and kinetic movement quantification.
Journal ArticleDOI
Advances and challenges in stroke rehabilitation.
TL;DR: Several large intervention trials targeting motor recovery report that participants' motor performance improved, but to a similar extent for both the intervention and control groups in most trials.
Journal ArticleDOI
BCI for stroke rehabilitation: motor and beyond.
TL;DR: The recent advances in BCI-based post-stroke motor rehabilitation are reviewed and the potential for the use of BCI systems beyond the motor domain is highlighted, in particular, in improving cognition and emotion of stroke patients.
Journal ArticleDOI
Shaping neuroplasticity by using powered exoskeletons in patients with stroke: a randomized clinical trial.
Rocco Salvatore Calabrò,Antonino Naro,Margherita Russo,Placido Bramanti,Luigi Carioti,Tina Balletta,Antonio Buda,Alfredo Manuli,Serena Filoni,Alessia Bramanti +9 more
TL;DR: Ekso™ gait training seems promising in gait rehabilitation for post-stroke patients, besides OGT, and the study proposes a putative neurophysiological basis supporting Ekso™ after-effects.
Journal ArticleDOI
Predicting Upper Limb Motor Impairment Recovery after Stroke: A Mixture Model
Rick van der Vliet,Ruud W. Selles,Eleni-Rosalina Andrinopoulou,Rinske H. M. Nijland,Rinske H. M. Nijland,Gerard M. Ribbers,Maarten A. Frens,Carel G. M. Meskers,Gert Kwakkel,Gert Kwakkel +9 more
TL;DR: The objectives were to develop a longitudinal mixture model of FM‐UE recovery, identify FM-UE recovery subgroups, and internally validate the model predictions.
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