D. R. Crapper McLachlan

TL;DR: Evidence is provided for a major early onset FAD locus on the long arm of chromosome 14 near the markers D14S43 and D 14S53 and it is suggested that the inheritance of FAD may be more complex than had initially been suspected.

TL;DR: The inheritance of five polymorphic DNA markers from the proximal long arm of chromosome 21 in a large unselected series of pedi-grees with familial Alzheimer's disease suggests that Alzheimer's Disease is not a single entity, but rather results from genetic defects on chromosome 21 and from other genetic or nongenetic factors.

TL;DR: It is indicated that by longitudinal neuropsychological evaluations and lab tests, which exclude other causes of dementia, the diagnosis of AD can be made even in severely and profoundly retarded patients.

TL;DR: The evidence, however, does not support an etiological role for aluminum in Alzheimer's disease, and the hypothesis that aluminum could be important in the pathogenesis of this neurodegenerative process is weakened.

TL;DR: There were no significant differences between exposed and non-exposed miners in reported diagnoses of neurological disorder; however, exposed miners performed less well than did unexposed workers on cognitive state examinations; also, the proportion of men with scores in the impaired range was greater in the exposed than non-Exposed group.