D
D. Steven Zatechka
Researcher at St. Jude Children's Research Hospital
Publications - 12
Citations - 373
D. Steven Zatechka is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: p38 mitogen-activated protein kinases & MAPK/ERK pathway. The author has an hindex of 7, co-authored 12 publications receiving 344 citations. Previous affiliations of D. Steven Zatechka include University of Nebraska–Lincoln.
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Journal ArticleDOI
Ars2 links the nuclear cap binding complex to RNA interference and cell proliferation
Joshua J. Gruber,D. Steven Zatechka,Leah R. Sabin,Jeongsik Yong,Julian J. Lum,Mei Kong,Wei-Xing Zong,Zhenxi Zhang,Chi Kong Lau,Jason S. Rawlings,Sara Cherry,James N. Ihle,Gideon Dreyfuss,Craig B. Thompson +13 more
TL;DR: Evidence is provided for a role for Ars2 in RNA interference regulation during cell proliferation and reduced the levels of several miRNAs, including miR-21, let-7, andMiR-155, that are implicated in cellular transformation.
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Studies of the Mitogen-activated Protein Kinases and Phosphatidylinositol-3 Kinase in the Lens. 1. The Mitogenic and Stress Responses‡
TL;DR: All the key members in the Raf-MEK-ERK cascade and PI-3K-Akt cascade were present and that growth factors had a differential stimulatory effect on them, and osmotic-induced activation could be normalized using an aldose reductase inhibitor.
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Diabetes can alter the signal transduction pathways in the lens of rats
TL;DR: Findings demonstrate diabetes-associated alterations in the lens signal transduction parameters and the effectiveness of AL01576 at normalizing such alterations and can be attributed to elevated vitreal bFGF in conjunction with osmotic stress and associated attenuation in redox status of the lens.
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MDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transport
Fan Zhang,Stacy L. Throm,Laura L. Murley,Laura Miller,D. Steven Zatechka,R. Kiplin Guy,Rachel Kennedy,Clinton F. Stewart,Clinton F. Stewart +8 more
TL;DR: It was confirmed that nutlin-3a increased the intracellular accumulation of BCRP substrates such as mitoxantrone and Hoechst 33342 in cells expressing functional BCRp without altering the expression level or localization of B CRP.
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Studies of the mitogen-activated protein kinases and phosphatidylinositol-3 kinase in the lens. 2. The intercommunications.
TL;DR: Data suggest that all the stimuli responses are mediated through phosphorylation and that the signaling among the mitogenic and stress response pathways is integrated through 'cross-talk' to process the most appropriate response.