L
Leah R. Sabin
Researcher at University of Pennsylvania
Publications - 16
Citations - 1464
Leah R. Sabin is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: RNA & RNA interference. The author has an hindex of 14, co-authored 16 publications receiving 1358 citations. Previous affiliations of Leah R. Sabin include Washington University in St. Louis.
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Journal ArticleDOI
Ars2 Regulates Both miRNA- and siRNA- Dependent Silencing and Suppresses RNA Virus Infection in Drosophila
Leah R. Sabin,Rui Zhou,Joshua J. Gruber,Nina Lukinova,Shelly Bambina,Allison Berman,Chi Kong Lau,Craig B. Thompson,Sara Cherry +8 more
TL;DR: It is shown that Ars2 plays an essential role in miRNA-mediated silencing, interacting with the Microprocessor and stabilizing pri-miRNAs, and provides new insight into the biogenesis of small RNAs that may be extended to other systems.
Journal ArticleDOI
Ars2 links the nuclear cap binding complex to RNA interference and cell proliferation
Joshua J. Gruber,D. Steven Zatechka,Leah R. Sabin,Jeongsik Yong,Julian J. Lum,Mei Kong,Wei-Xing Zong,Zhenxi Zhang,Chi Kong Lau,Jason S. Rawlings,Sara Cherry,James N. Ihle,Gideon Dreyfuss,Craig B. Thompson +13 more
TL;DR: Evidence is provided for a role for Ars2 in RNA interference regulation during cell proliferation and reduced the levels of several miRNAs, including miR-21, let-7, andMiR-155, that are implicated in cellular transformation.
Journal ArticleDOI
Global Analysis of RNA Secondary Structure in Two Metazoans
Fan Li,Qi Zheng,Paul Ryvkin,Isabelle Dragomir,Yaanik Desai,Subhadra Aiyer,Otto Valladares,Jamie Yang,Shelly Bambina,Leah R. Sabin,John I. Murray,Todd Lamitina,Arjun Raj,Sara Cherry,Li-San Wang,Brian D. Gregory +15 more
TL;DR: A high-throughput, sequencing-based, structure-mapping approach is used to identify the paired and unpaired components of the Drosophila melanogaster and Caenorhabditis elegans transcriptomes, which allows us to identify conserved features of RNA secondary structure in metazoans.
Journal ArticleDOI
The exoribonuclease Nibbler controls 3' end processing of microRNAs in Drosophila.
Nan Liu,Masashi Abe,Leah R. Sabin,Gert-Jan Hendriks,Ammar S. Naqvi,Zhenming Yu,Sara Cherry,Nancy M. Bonini +7 more
TL;DR: Deep sequencing analysis revealed a larger set of multi-isoform miRNAs that are controlled by nibbler, suggesting that Nbr-mediated 3' end processing represents a critical step in miRNA maturation that impacts miRNA diversity.
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Innate antiviral immunity in Drosophila.
TL;DR: This review will highlight the recent discoveries in antiviral immunity in insects and will reveal some of the lessons learned.