D
Dae Hee Lee
Researcher at Korea University
Publications - 82
Citations - 3699
Dae Hee Lee is an academic researcher from Korea University. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 25, co-authored 80 publications receiving 2943 citations. Previous affiliations of Dae Hee Lee include Korea University Medical Center & University of Virginia.
Papers
More filters
Journal ArticleDOI
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha.
A Soeda,M Park,Dae Hee Lee,Arlan Mintz,Andreas Androutsellis-Theotokis,Ronald D.G. McKay,Johnathan A. Engh,Toru Iwama,Takahiro Kunisada,Amin B. Kassam,Ian F. Pollack,Deric M. Park +11 more
TL;DR: It is shown that hypoxia (1% oxygen) promotes the self-renewal capacity of CD133-positive human glioma-derived cancer stem cells (CSCs) and the activation of HIF-1α to enhance theSelf-Renewal activity of CD 133-positive cells and to inhibit the induction of CSC differentiation.
Journal ArticleDOI
Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation
Hyunju Chung,Eunhee Kim,Dae Hee Lee,Sanghee Seo,Sunghee Ju,Dahm Lee,Hocheol Kim,Seungjoon Park +7 more
TL;DR: Ghrelin may act as a survival factor that preserves mitochondrial integrity and inhibits apoptotic pathways in neuronal cells and in vivo administration of ghrelin significantly reduced infarct volume in an animal model of ischemia.
Journal ArticleDOI
Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro
TL;DR: Astaxanthin shows protection from MPP+/MPTP-induced apoptosis in the SH-SY5Y cells and PD model mouse SN neurons, and this effect may be attributable to upregulation of the expression of Bcl-2 protein, down regulation of theexpression of Bax and α-synuclein, and inhibition of the activation of caspase-3.
Journal ArticleDOI
Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis.
TL;DR: This review highlights the recent literature on ferroptotic and apoptotic agent interactions through the ER stress–mediated PERK–eIF2α–ATF4–CHOP–PUMA pathway and implicates combined treatment to effectively enhance tumoricidal efficacy as a novel therapeutic strategy for cancer.
Journal ArticleDOI
Quercetin augments TRAIL-induced apoptotic death: Involvement of the ERK signal transduction pathway
TL;DR: Quercetin enhances TRAIL induced apoptosis by inhibition of survivin expression, through ERK-MSK1-mediated deacetylation of H3.