D
Daisuke Fujikura
Researcher at Hokkaido University
Publications - 37
Citations - 836
Daisuke Fujikura is an academic researcher from Hokkaido University. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 15, co-authored 36 publications receiving 720 citations. Previous affiliations of Daisuke Fujikura include Asahikawa Medical University.
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Journal ArticleDOI
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses
Sumio Hayakawa,Souichi Shiratori,Hiroaki Yamato,Takeshi Kameyama,Chihiro Kitatsuji,Fumi Kashigi,Showhey Goto,Shoichiro Kameoka,Daisuke Fujikura,Taisho Yamada,Tatsuaki Mizutani,Mika Kazumata,Maiko Sato,Junji Tanaka,Masahiro Asaka,Yusuke Ohba,Tadaaki Miyazaki,Masahiro Imamura,Akinori Takaoka +18 more
TL;DR: ZAPS was selectively induced by 5′-triphosphate–modified RNA (3pRNA) and functioned as a potent stimulator of interferon responses in human cells mediated by the RNA helicase RIG-I, suggesting its possible use as a therapeutic target for viral control.
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Interaction between TIM-1 and NPC1 Is Important for Cellular Entry of Ebola Virus
Makoto Kuroda,Daisuke Fujikura,Asuka Nanbo,Andrea Marzi,Osamu Noyori,Masahiro Kajihara,Junki Maruyama,Keita Matsuno,Hiroko Miyamoto,Reiko Yoshida,Heinz Feldmann,Ayato Takada +11 more
TL;DR: It is demonstrated that TIM-1 and NPC1, which serve as attachment and fusion receptors for filovirus entry, interact in the intracellular vesicles where Ebola virus GP-mediated membrane fusion occurs and that this interaction is important forfilovirus infection.
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Heat Shock Protein 70 Modulates Influenza A Virus Polymerase Activity
Rashid Manzoor,Kazumichi Kuroda,Reiko Yoshida,Yoshimi Tsuda,Daisuke Fujikura,Hiroko Miyamoto,Masahiro Kajihara,Hiroshi Kida,Ayato Takada,Ayato Takada +9 more
TL;DR: For the first time, these findings suggest that Hsp70 may act as a chaperone for influenza virus polymerase, and the modulatory effect of H Sp70 appears to be a sequel of shuttling of HSp70 between nuclear and cytoplasmic compartments.
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Functional role of death-associated protein 3 (DAP3) in anoikis.
Tadaaki Miyazaki,Tadaaki Miyazaki,Min Shen,Daisuke Fujikura,Noriko Tosa,Hyung-Ryong Kim,Shigeyuki Kon,Toshimitsu Uede,John C. Reed +8 more
TL;DR: Involvement of DAP3 in anoikis signaling demonstrates a novel role for this GTP-binding protein in apoptosis induction caused by cell detachment, and shows that D AP3 is phosphorylated by kinase Akt (PKB), and active Akt can nullify apoptotic induction by DAP2.
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Programmed Cell Death in the Pathogenesis of Influenza
TL;DR: This work reviews the current understanding of mechanisms of programmed cell death in the pathogenesis of influenza and shows that there are different types of programmedcell death that vary in terms of molecular mechanisms and/or associations with inflammation.