G
Gefeng Zhu
Researcher at Johns Hopkins University
Publications - 40
Citations - 14630
Gefeng Zhu is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 31, co-authored 39 publications receiving 13313 citations. Previous affiliations of Gefeng Zhu include Loyola University Chicago & Mayo Clinic.
Papers
More filters
Journal ArticleDOI
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
Haidong Dong,Scott E. Strome,Diva R. Salomao,Hideto Tamura,Fumiya Hirano,Dallas B. Flies,Patrick C. Roche,Jun Lu,Gefeng Zhu,Koji Tamada,Vanda A. Lennon,Esteban Celis,Lieping Chen +12 more
TL;DR: It is reported here that, except for cells of the macrophage lineage, normal human tissues do not express B7-H1 and the findings have implications for the design of T cell–based cancer immunotherapy.
Journal ArticleDOI
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
TL;DR: A previously unknown co-stimulatory molecule that may be involved in the negative regulation of cell-mediated immune responses is defined.
Journal Article
Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity
Fumiya Hirano,Katsumi Kaneko,Hideto Tamura,Haidong Dong,Shengdian Wang,Shengdian Wang,Masao Ichikawa,Masao Ichikawa,Cecilia Rietz,Cecilia Rietz,Dallas B. Flies,Dallas B. Flies,Julie S. Lau,Gefeng Zhu,Gefeng Zhu,Koji Tamada,Koji Tamada,Lieping Chen,Lieping Chen +18 more
TL;DR: It is reported here that constitutive or inducible expression of B7-H1, a B7 family molecule widely expressed by cancers, confers resistance to therapeutic anti-CD137 antibody in mice with established tumors and implicate new approaches for immunotherapy of human cancers.
Journal ArticleDOI
B7-H3: A costimulatory molecule for T cell activation and IFN-γ production
Andrei I. Chapoval,Jian Ni,Julie S. Lau,Ryan A. Wilcox,Dallas B. Flies,Ding Liu,Haidong Dong,Gabriel Sica,Gefeng Zhu,Koji Tamada,Lieping Chen +10 more
TL;DR: A newly identified member of the human B7 family, designated B7 homolog 3 (B7-H3), that shares 20–27% amino acid identity with other B7family members is described, that may participate in the regulation of cell-mediated immune responses.
Journal ArticleDOI
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
Ilona Kryczek,Ilona Kryczek,Linhua Zou,Linhua Zou,Paulo C. Rodriguez,Gefeng Zhu,Shuang Wei,Shuang Wei,Peter Mottram,Michael J. Brumlik,Pui Cheng,Tyler J. Curiel,Leann Myers,Andrew A. Lackner,Xavier Alvarez,Augusto C. Ochoa,Lieping Chen,Weiping Zou,Weiping Zou +18 more
TL;DR: B7-H4+ tumor macrophages constitute a novel suppressor cell population in ovarian cancer and represent a critical checkpoint in determining host responses to dysfunctional cytokines in ovariancancer.