Vasiliki Triantafyllia

TL;DR: Lambda interferons (IFN&lgr;s) or type III IFNs share homology, expression patterns, signaling cascades, and antiviral functions with type I IFNs, and are shown to provide front‐line antiviral protection without activating inflammation.

TL;DR: A dysregulated interferon response whereby IFN-λ and type I IFN production were diminished and delayed in patients with COVID-19, exhibiting a response that is ‘untuned’ with other inflammatory cytokines is reported.

TL;DR: In this paper, the authors found that auto-antibodies neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections.

TL;DR: Altered cytokine patterns in COVID-19 patients correlate with longer hospitalization time and higher incidence of critical disease and mortality compared to flu, pointing to an untuned antiviral response in CO VID-19 contributing to persistent viral presence, hyperinflammation and respiratory failure.

TL;DR: It is found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women.