D
Daniel C. Chung
Researcher at Harvard University
Publications - 307
Citations - 27050
Daniel C. Chung is an academic researcher from Harvard University. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 69, co-authored 290 publications receiving 24211 citations. Previous affiliations of Daniel C. Chung include University of Pennsylvania & Google.
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Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
Christopher G. Willett,Yves Boucher,Emmanuelle di Tomaso,Dan G. Duda,Lance L. Munn,Ricky T. Tong,Daniel C. Chung,Dushyant V. Sahani,Sanjeeva P. Kalva,Sergey V. Kozin,Mari Mino,Kenneth S. Cohen,David T. Scadden,Alan C. Hartford,Alan J. Fischman,Jeffrey W. Clark,David P. Ryan,Andrew X. Zhu,Lawrence S. Blaszkowsky,Helen X. Chen,Paul C. Shellito,Gregory Y Lauwers,Rakesh K. Jain +22 more
TL;DR: It is shown that a single infusion of the VEGF-specific antibody bevacizumab decreases tumor perfusion, vascular volume, microvascular density, interstitial fluid pressure and the number of viable, circulating endothelial and progenitor cells, and increases the fraction of vessels with pericyte coverage in rectal carcinoma patients.
Journal Article
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
Christopher G. Willett,Yves Boucher,Emmanuelle di Tomaso,Dan G. Duda,Lance L. Munn,Ricky T. Tong,Daniel C. Chung,Dushyant V. Sahani,Sanjeeva P. Kalva,Sergey V. Kozin,Mari Mino,Kenneth S. Cohen,David T. Scadden,Alan C. Hartford,Alan J. Fischman,Jeffrey W. Clark,David P. Ryan,Andrew X. Zhu,Lawrence S. Blaszkowsky,Helen X. Chen,Paul C. Shellito,Gregory Y Lauwers,Rakesh K. Jain +22 more
TL;DR: In this article, a single infusion of the VEGF-specific antibody bevacizumab decreases tumor perfusion, vascular volume, microvascular density, interstitial fluid pressure and the number of viable, circulating endothelial and progenitor cells, and increases the fraction of vessels with pericyte coverage in rectal carcinoma patients.
Journal ArticleDOI
Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment
Aleksandar Kostic,Aleksandar Kostic,Eunyoung Chun,Lauren Robertson,Jonathan N. Glickman,Carey Ann Gallini,Monia Michaud,Thomas E. Clancy,Thomas E. Clancy,Daniel C. Chung,Paul Lochhead,Georgina L. Hold,Emad M. El-Omar,Dean E. Brenner,Charles S. Fuchs,Matthew Meyerson,Matthew Meyerson,Wendy S. Garrett +17 more
TL;DR: Data suggest that, through recruitment of tumor-infiltrating immune cells, fusobacteria generate a proinflammatory microenvironment that is conducive for colorectal neoplasia progression, and this work finds that F.nucleatum does not exacerbate colitis, enteritis, or inflammation-associated intestinal carcinogenesis.
Journal ArticleDOI
Gastroenteropancreatic neuroendocrine tumours.
Irvin M. Modlin,Kjell Öberg,Daniel C. Chung,Robert T. Jensen,Wouter W. de Herder,Rajesh V. Thakker,Martyn Caplin,Gianfranco Delle Fave,Greg Kaltsas,Eric P. Krenning,Steven F. Moss,Ola Nilsson,Guido Rindi,Ramon Salazar,Philippe Ruszniewski,Anders Sundin +15 more
TL;DR: To improve outcome from GEP NETs, a better understanding of their biology is needed, with emphasis on molecular genetics and disease modeling, and more-reliable serum markers, better tumour localisation and identification of small lesions, and histological grading systems and classifications with prognostic application are needed.
Journal ArticleDOI
Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial
Stephen R. Russell,Jean Bennett,Jennifer Wellman,Daniel C. Chung,Zi Fan Yu,Amy Tillman,Janet Wittes,Julie Pappas,Okan U. Elci,Sarah McCague,Dominique Cross,Kathleen A. Marshall,Jean Walshire,Taylor Kehoe,Hannah Reichert,Maria C. Davis,Leslie Raffini,Lindsey A. George,F. Parker Hudson,Laura E. Dingfield,Xiaosong Zhu,Julia A. Haller,Elliott H. Sohn,Vinit B. Mahajan,Wanda Pfeifer,Michelle T. Weckmann,Chris A. Johnson,Dina Y. Gewaily,Arlene V. Drack,Edwin M. Stone,Katie Wachtel,Francesca Simonelli,Bart P. Leroy,Bart P. Leroy,J. Fraser Wright,Katherine A. High,Albert M. Maguire +36 more
TL;DR: Voretigene neparvovec gene replacement improved functional vision in RPE65-mediated inherited retinal dystrophy previously medically untreatable.