Daniel E. Cohen

TL;DR: Despite widespread cross-presentation of identical HIV-1 peptides in HIV- 1-infected individuals expressing HLA-A3 or Hla-A11, peptides presented by HLA's commonly exhibited clear immune distinctiveness with exclusive TCR recognition, it is shown that specific TCRs can cross-recognize their antigen in the context of both HLA’s.

TL;DR: It is demonstrated that the clustering of HIV-1-specific T cell responses is influenced by the genetic HLA class I background in the study populations, which means specific regions of the virus can be expected to be differentially targeted in ethnically diverse populations.

TL;DR: In this article , an ACE2-Fc fusion protein, SI-F019, was presented for the treatment of COVID-19, which is not compromised, but actually strengthened, by the mutations of dominant variants including Omicron.

TL;DR: Any primary care provider may be called on to care for a patient living with HIV, and it is incumbent on all medical providers to become proficient in the management of this complex infection.

TL;DR: It is suggested that asymptomatic urethral chlamydia and gonorrhea may be uncommon in MSM living in the greater Boston area and that the recent rise in the prevalence of sexually transmitted infections may not be due to untreated asymPTomatic infections.