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Xu G. Yu
Researcher at Ragon Institute of MGH, MIT and Harvard
Publications - 157
Citations - 13537
Xu G. Yu is an academic researcher from Ragon Institute of MGH, MIT and Harvard. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 49, co-authored 152 publications receiving 9827 citations. Previous affiliations of Xu G. Yu include Harvard University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host.
Bina Choi,Manish Chandra Choudhary,James Regan,Jeffrey A. Sparks,Robert F. Padera,Xueting Qiu,Isaac H. Solomon,Hsiao Hsuan Kuo,Julie Boucau,Kathryn Bowman,U. Das Adhikari,Marisa L. Winkler,Alisa A. Mueller,Tiffany Y.T. Hsu,Michaël Desjardins,Lindsey R. Baden,Brian Chan,Bruce D. Walker,Mathias Lichterfeld,Manfred Brigl,Douglas S. Kwon,Sanjat Kanjilal,Eugene T Richardson,A. Helena Jonsson,Galit Alter,Amy K. Barczak,William P. Hanage,Xu G. Yu,Gaurav D. Gaiha,Michael S. Seaman,Manuela Cernadas,Jonathan Z. Li +31 more
TL;DR: An immunocompromised patient who had persistent infection with SARS-CoV-2 over a period of months, despite several courses of treatment, is described.
Journal ArticleDOI
Comprehensive Epitope Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses Directed against the Entire Expressed HIV-1 Genome Demonstrate Broadly Directed Responses, but No Correlation to Viral Load
Marylyn M. Addo,Xu G. Yu,Almas Rathod,Daniel E. Cohen,Robert L. Eldridge,Daryld Strick,Mary N. Johnston,Colleen Corcoran,Alysse G. Wurcel,Cecily A. Fitzpatrick,Margaret E. Feeney,William Rodriguez,Nesli Basgoz,Rika Draenert,David Stone,Christian Brander,Philip J. R. Goulder,Philip J. R. Goulder,Eric S. Rosenberg,Marcus Altfeld,Bruce D. Walker +20 more
TL;DR: The data suggest that the impact of T-cell responses on control of viral replication cannot be explained by the mere quantification of the magnitude and breadth of the CD8+-T-cell response, even if a comprehensive pan-genome screening approach is applied.
Journal ArticleDOI
SARS-CoV-2 viral load is associated with increased disease severity and mortality.
Jesse Fajnzylber,James Regan,Kendyll Coxen,Heather Corry,Colline Wong,Alexandra Rosenthal,Daniel P Worrall,Francoise Giguel,Alicja Piechocka-Trocha,Caroline Atyeo,Stephanie Fischinger,Andrew T. Chan,Keith T. Flaherty,Kathryn T. Hall,Michael Dougan,Edward T. Ryan,Elizabeth Gillespie,Rida Chishti,Yijia Li,Nikolaus Jilg,Nikolaus Jilg,Dusan Hanidziar,Rebecca M. Baron,Lindsey R. Baden,Athe M. N. Tsibris,Katrina Armstrong,Daniel R. Kuritzkes,Galit Alter,Galit Alter,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Xu G. Yu,Xu G. Yu,Jonathan Z. Li +34 more
TL;DR: It is reported that a higher prevalence of detectable SARS-CoV-2 plasma viral load is associated with worse respiratory disease severity, lower absolute lymphocyte counts, and increased markers of inflammation, including C-reactive protein and IL-6.
Journal ArticleDOI
Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19.
Naoki Kaneko,Hsiao-Hsuan Kuo,Julie Boucau,Jocelyn R. Farmer,Hugues Allard-Chamard,Vinay Mahajan,Alicja Piechocka-Trocha,Kristina Lefteri,Matthew Osborn,Julia Bals,Yannic C. Bartsch,Nathalie Bonheur,Timothy M. Caradonna,Josh Chevalier,Fatema Z. Chowdhury,Thomas J. Diefenbach,Kevin Einkauf,Jon Fallon,Jared Feldman,Kelsey K. Finn,Pilar Garcia-Broncano,Ciputra Adijaya Hartana,Blake M. Hauser,Chenyang Jiang,Paulina Kaplonek,Marshall Karpell,Eric C. Koscher,Xiao-Dong Lian,Hang Liu,Jinqing Liu,Ngoc L. Ly,Ashlin R. Michell,Yelizaveta Rassadkina,Kyra Seiger,Libera Sessa,Sally Shin,Nishant K. Singh,Weiwei Sun,Xiaoming Sun,Hannah J. Ticheli,Michael T. Waring,Alex Lee Zhu,Galit Alter,Jonathan Z. Li,Daniel Lingwood,Aaron G. Schmidt,Mathias Lichterfeld,Bruce D. Walker,Xu G. Yu,Robert F. Padera,Shiv Pillai +50 more
TL;DR: Data identify defective Bcl-6+ TFH cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections and suggest that achieving herd immunity through natural infection may be difficult.
Journal ArticleDOI
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity.
Ellen Shrock,Ellen Shrock,Eric Fujimura,Eric Fujimura,Tomasz Kula,Tomasz Kula,Richard T. Timms,Richard T. Timms,I-Hsiu Lee,Yumei Leng,Yumei Leng,Matthew L Robinson,Brandon M. Sie,Brandon M. Sie,Mamie Z. Li,Mamie Z. Li,Yuezhou Chen,Jennifer K. Logue,Adam Zuiani,Denise J. McCulloch,Felipe J.N. Lelis,Stephanie A. Henson,Daniel R. Monaco,Meghan Travers,Shaghayegh Habibi,William Clarke,Patrizio Caturegli,Oliver Laeyendecker,Oliver Laeyendecker,Alicja Piechocka-Trocha,Jonathan Z. Li,Ashok Khatri,Helen Y. Chu,Alexandra-Chloé Villani,Kyle R. Kays,Marcia B. Goldberg,Nir Hacohen,Michael R. Filbin,Xu G. Yu,Bruce D. Walker,Bruce D. Walker,Duane R. Wesemann,H. Benjamin Larman,James A. Lederer,Stephen J. Elledge,Stephen J. Elledge +45 more
TL;DR: A systematic characterization of the humoral response to severe acute respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed, important for understanding the immunogenicity of the viral proteome and the basis for cross-reactivity with the common-cold coronaviruses.