M
Mathias Lichterfeld
Researcher at Brigham and Women's Hospital
Publications - 165
Citations - 10934
Mathias Lichterfeld is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 50, co-authored 141 publications receiving 8692 citations. Previous affiliations of Mathias Lichterfeld include University of Texas MD Anderson Cancer Center & University Hospital Bonn.
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Journal ArticleDOI
Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host.
Bina Choi,Manish Chandra Choudhary,James Regan,Jeffrey A. Sparks,Robert F. Padera,Xueting Qiu,Isaac H. Solomon,Hsiao Hsuan Kuo,Julie Boucau,Kathryn Bowman,U. Das Adhikari,Marisa L. Winkler,Alisa A. Mueller,Tiffany Y.T. Hsu,Michaël Desjardins,Lindsey R. Baden,Brian Chan,Bruce D. Walker,Mathias Lichterfeld,Manfred Brigl,Douglas S. Kwon,Sanjat Kanjilal,Eugene T Richardson,A. Helena Jonsson,Galit Alter,Amy K. Barczak,William P. Hanage,Xu G. Yu,Gaurav D. Gaiha,Michael S. Seaman,Manuela Cernadas,Jonathan Z. Li +31 more
TL;DR: An immunocompromised patient who had persistent infection with SARS-CoV-2 over a period of months, despite several courses of treatment, is described.
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Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19.
Naoki Kaneko,Hsiao-Hsuan Kuo,Julie Boucau,Jocelyn R. Farmer,Hugues Allard-Chamard,Vinay Mahajan,Alicja Piechocka-Trocha,Kristina Lefteri,Matthew Osborn,Julia Bals,Yannic C. Bartsch,Nathalie Bonheur,Timothy M. Caradonna,Josh Chevalier,Fatema Z. Chowdhury,Thomas J. Diefenbach,Kevin Einkauf,Jon Fallon,Jared Feldman,Kelsey K. Finn,Pilar Garcia-Broncano,Ciputra Adijaya Hartana,Blake M. Hauser,Chenyang Jiang,Paulina Kaplonek,Marshall Karpell,Eric C. Koscher,Xiao-Dong Lian,Hang Liu,Jinqing Liu,Ngoc L. Ly,Ashlin R. Michell,Yelizaveta Rassadkina,Kyra Seiger,Libera Sessa,Sally Shin,Nishant K. Singh,Weiwei Sun,Xiaoming Sun,Hannah J. Ticheli,Michael T. Waring,Alex Lee Zhu,Galit Alter,Jonathan Z. Li,Daniel Lingwood,Aaron G. Schmidt,Mathias Lichterfeld,Bruce D. Walker,Xu G. Yu,Robert F. Padera,Shiv Pillai +50 more
TL;DR: Data identify defective Bcl-6+ TFH cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections and suggest that achieving herd immunity through natural infection may be difficult.
Journal ArticleDOI
Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial
Thomas A Rasmussen,Martin Tolstrup,Christel R. Brinkmann,Rikke Olesen,Christian Erikstrup,Ajantha Solomon,Anni Winckelmann,Sarah Palmer,Charles A. Dinarello,Maria J. Buzon,Maria J. Buzon,Mathias Lichterfeld,Mathias Lichterfeld,Sharon R Lewin,Sharon R Lewin,Lars Østergaard,Ole S. Søgaard +16 more
TL;DR: Panobinostat effectively disrupts HIV latency in vivo and is a promising candidate for future combination clinical trials aimed at HIV eradication, however, panobinostats did not reduce the number of latently infected cells and this approach may need to be combined with others to significantly affect the latent HIV reservoir.
Journal ArticleDOI
HIV-1 persistence in CD4+ T cells with stem cell-like properties
Maria J. Buzon,Hong Sun,Chun Li,Amy Shaw,Katherine Seiss,Zhengyu Ouyang,Enrique Martin-Gayo,Jin Leng,Timothy J. Henrich,Jonathan Z. Li,Florencia Pereyra,Ryan Zurakowski,Bruce D. Walker,Eric S. Rosenberg,Xu G. Yu,Mathias Lichterfeld +15 more
TL;DR: HIV-1 may exploit the stem cell characteristics of cellular immune memory to promote long-term viral persistence of viral quasispecies in CD4+ TSCM cells.
Journal ArticleDOI
Loss of HIV-1–specific CD8+ T Cell Proliferation after Acute HIV-1 Infection and Restoration by Vaccine-induced HIV-1–specific CD4+ T Cells
Mathias Lichterfeld,Daniel Kaufmann,Xu G. Yu,Stanley K. Mui,Marylyn M. Addo,Mary N. Johnston,Daniel E. Cohen,Gregory K. Robbins,Eunice Pae,Galit Alter,Alysse G. Wurcel,Alysse G. Wurcel,David Stone,Eric S. Rosenberg,Bruce D. Walker,Bruce D. Walker,Marcus Altfeld +16 more
TL;DR: It is demonstrated that HIV-1–specific CD8+ T cells proliferate rapidly upon encounter with cognate antigen in acute infection, but lose this capacity with ongoing viral replication, and can be restored in chronic infection by augmentation of HIV- 1–specific T helper cell function.