D
Daniel E. Gottschling
Researcher at Fred Hutchinson Cancer Research Center
Publications - 81
Citations - 15597
Daniel E. Gottschling is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Gene & Saccharomyces cerevisiae. The author has an hindex of 49, co-authored 79 publications receiving 14753 citations. Previous affiliations of Daniel E. Gottschling include University of Illinois at Chicago & University of Colorado Boulder.
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Journal ArticleDOI
Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena
Kelly Kruger,Paula J. Grabowski,Arthur J. Zaug,Julie Sands,Daniel E. Gottschling,Thomas R. Cech +5 more
TL;DR: It is proposed that the IVS portion of the RNA has several enzyme-like properties that enable it to break and reform phosphodiester bonds and that enzymes, small nuclear RNAs and folding of the pre-rRNA into an RNP are unnecessary for these reactions.
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Position Effect at S. cerevisiae Telomeres: Reversible Repression of Pol II Transcription
TL;DR: Yeast telomeres exert a position effect on the transcription of nearby genes, an effect that is under epigenetic control as demonstrated by phenotype and mRNA analyses.
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The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote
Dirk Schübeler,David M. MacAlpine,David Scalzo,Christiane Wirbelauer,Charles Kooperberg,Fred van Leeuwen,Daniel E. Gottschling,Laura P. O'Neill,Bryan M. Turner,Jeffrey J. Delrow,Stephen P. Bell,Mark Groudine +11 more
TL;DR: A genome-wide chromatin structure analysis in a higher eukaryote found a binary pattern of histone modifications among euchromatic genes, with active genes being hyperacetylated for H3 and H4 and hypermethylated at Lys 4 and Lys 79 of H3, and inactive genes being hypomethylated and deacetylation at the same residues.
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Dot1p Modulates Silencing in Yeast by Methylation of the Nucleosome Core
TL;DR: DOT1 was originally identified as a gene affecting telomeric silencing in S. cerevisiae, but it is found that Dot1p methylates histone H3 on lysine 79, which maps to the top and bottom of the nucleosome core.
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TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
TL;DR: The discovery of TLC1 confirms the existence of telomerase in S. cerevisiae and may facilitate both the analysis of this enzyme and an understanding of telomere structure and function.