D
Daniel Graf
Researcher at University of Alberta
Publications - 101
Citations - 6177
Daniel Graf is an academic researcher from University of Alberta. The author has contributed to research in topics: Bone morphogenetic protein & T cell. The author has an hindex of 34, co-authored 90 publications receiving 5795 citations. Previous affiliations of Daniel Graf include Hammersmith Hospital & Alexander Fleming Biomedical Sciences Research Center.
Papers
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Journal ArticleDOI
Identification of Cd36 ( Fat ) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
Timothy J. Aitman,Anne M. Glazier,Caroline A. Wallace,Lisa D. Cooper,Penny J. Norsworthy,Faisal N. Wahid,Khulood M. Al-Majali,Paul M. Trembling,Christopher J. Mann,Carol C. Shoulders,Daniel Graf,Elizabeth St. Lezin,Theodore W. Kurtz,Vladimir Kren,Vladimir Kren,M Pravenec,M Pravenec,Azeddine Ibrahimi,Nada A. Abumrad,Lawrence W. Stanton,James Scott +20 more
TL;DR: It is concluded that Cd36 deficiency underlies insulin resistance, defective fatty acid metabolism and hypertriglyceridaemia in SHR and may be important in the pathogenesis of human insulin-resistance syndromes.
Journal ArticleDOI
Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM
Ulf Korthäuer,Daniel Graf,Hans W. Mages,Francine Brière,M Padayachee,Sue Malcolm,Alberto G. Ugazio,Luigi D. Notarangelo,Roland J. Levinsky,Richard A. Kroczek +9 more
TL;DR: Evidence is presented that point mutations in the TRAP gene give rise to nonfunctional or defective expression of TRAP on the surface of T cells in patients with HIGM1, which is responsible for the observed immunoglobulin isotype defect in HIGm1.
Journal ArticleDOI
A role for Dicer in immune regulation.
Bradley S. Cobb,Arnulf Hertweck,James Smith,Eric D. O'Connor,Daniel Graf,H. Terence Cook,Stephen T. Smale,Shimon Sakaguchi,Frederick J. Livesey,Frederick J. Livesey,Amanda G. Fisher,Matthias Merkenschlager +11 more
TL;DR: It is shown that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells, and results suggest that T reg cell development involves Dicer-generated RNAs.
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Dynamic Repositioning of Genes in the Nucleus of Lymphocytes Preparing for Cell Division
TL;DR: It is shown that several transcriptionally inactive genes localize to centromeric heterochromatin in the nucleus of cycling but not quiescent (noncycling) primary B lymphocytes, and locus repositioning may be a feature of heritable gene silencing.
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Cloning of TRAP, a ligand for CD40 on human T cells
TL;DR: A cDNA clone, designated TRAP (TNF‐related activation protein), isolated from a collection of T cell activation genes, is highly similar to an identified murine CD40 ligand both at the cDNA and the protein levels, and related to tumor necrosis factor/lymphotoxin.